Favorable impact of growth hormone treatment on cholesterol levels in turner syndrome

Hitoshi Kohno Dr., Yutaka Igarashi, Keiichi Ozono, Kenji Ohyama, Masamichi Ogawa, Hisao Osada, Kazumichi Onigata, Susumu Kanzaki, Yoshiki Seino, Hiroaki Takahashi, Toshihiro Tajima, Katsuhiko Tachibana, Hiroyuki Tanaka, Yoshikazu Nishi, Tomonobu Hasegawa, Kenji Fujieda, Keinosuke Fujita, Reiko Horikawa, Susumu Yokoya, Toru YorifujiToshiaki Tanaka

研究成果: Article査読

5 被引用数 (Scopus)

抄録

Background: Patients with Turner syndrome (TS) are prone to having metabolic abnormalities, such as obesity, dyslipidemia, hypertension, hyperinsulinemia and type 2 diabetes mellitus, resulting in increased risks of developing atherosclerotic diseases. Objective: To determine the effect of growth hormone (GH) therapy on serum cholesterol levels in prepubertal girls with TS enrolled in the Turner syndrome Research Collaboration (TRC) in Japan. Patients and methods: Eighty-one girls with TS were enrolled in the TRC, and their total cholesterol (TC) levels before GH therapy were compared with reported levels of healthy school-aged Japanese girls. TC levels after 1, 2 and 3 yr of GH treatment were available for 28 of the 81 patients with TS. GH was administered by daily subcutaneous injections, 6 or 7 times/wk, with a weekly dose of 0.35 mg/kg body weight. Results: Baseline TC levels revealed an age-related increase in TS that was in contrast to healthy girls showing unchanged levels. During GH therapy, TC decreased significantly after 1 yr of GH treatment and remained low thereafter. Conclusions: Girls with untreated TS showed an age-related increase in TC that was a striking contrast to healthy girls, who showed unchanged levels. GH therapy in girls with TS brought about a favorable change in TC that indicates the beneficial impact of GH on atherogenic risk.

本文言語English
ページ(範囲)29-34
ページ数6
ジャーナルclinical pediatric endocrinology
21
2
DOI
出版ステータスPublished - 2012

ASJC Scopus subject areas

  • 小児科学、周産期医学および子どもの健康
  • 内分泌学、糖尿病および代謝内科学
  • 内分泌学

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