Feedback Mechanism Between Blood Vessels and Astrocytes in Retinal Vascular development

Yoshiaki Kubota, Toshio Suda

研究成果: Review article査読

29 被引用数 (Scopus)

抄録

To meet tissue requirements for oxygen, blood vessels are efficiently distributed throughout the body. Multiple interactions between the vasculature and surrounding tissues are involved in this process. Retinal vascular development is controlled by interactions between ganglion cells, astrocytes, and endothelial cells. In particular, reciprocal feedback between endothelial cells and astrocytes is crucial for proper vascular patterning. Hypoxia-induced vascular endothelial growth factor expression in astrocytes plays a key role in retinal vascular growth. Recently, leukemia inhibitory factor secreted from endothelial cells was shown to act cooperatively with oxygen as a negative feedback signal. This reciprocal feedback mechanism provides a promising target for novel antiangiogenic strategies against ocular neovascular diseases and cancers. Here, we briefly review what is currently known about the molecular events involved in the cellular interactions between ganglion cells, astrocytes, and endothelial cells that control retinal vascular patterning.

本文言語English
ページ(範囲)38-43
ページ数6
ジャーナルTrends in Cardiovascular Medicine
19
2
DOI
出版ステータスPublished - 2009 2月
外部発表はい

ASJC Scopus subject areas

  • 循環器および心血管医学

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