Fetal goitrous hypothyroidism followed by neonatal transient hyperthyroidism: A case report

Tadashi Matsumoto, Kei Miyakoshi, Kenji Kasai, Hitoshi Ishimoto, Mamoru Tanaka, Kazushige Ikeda, Yasunori Yoshimura

研究成果: Article査読

11 被引用数 (Scopus)

抄録

We report a case of fetal goitrous hypothyroidism followed by neonatal transient hyperthyroidism. A fetal goiter (26 × 38 mm) was detected by ultrasound and magnetic resonance imaging at 29 weeks of gestation. Hypothyroidism was confirmed by cordocentesis, which revealed an elevated TSH (255 μIU/ml) and a low free T4 (0.4 ng/dl). The fetal goiter decreased in size after treatment with four 240-microgram intra-amniotic administrations of levothyroxine. A 2,829-gram male neonate was delivered vaginally at 37 weeks of gestation, showing an euthyroid status at birth. On day 3, free T3 was 6.9 pg/ ml and free T4 was 6.4 ng/dl, indicating hyperthyroidism. This persisted for 4 months. His thyroid functions reverted to normal at 4 months of age and have been within normal range since. Undetermined factors might be involved in the development of thyroid dysfunction in the perinatal period.

本文言語English
ページ(範囲)459-462
ページ数4
ジャーナルFetal Diagnosis and Therapy
18
6
DOI
出版ステータスPublished - 2003 11 7

ASJC Scopus subject areas

  • 小児科学、周産期医学および子どもの健康
  • 胎生学
  • 放射線学、核医学およびイメージング
  • 産婦人科学

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