Fetal skin possesses the ability to regenerate completely: Complete regeneration of skin

研究成果: Article

29 引用 (Scopus)

抄録

Until a certain developmental stage, cutaneous wounds in mammalian fetuses heal rapidly without scars with complete regeneration of the skin. In the process of fetal wound healing, infammatory responses, granulation proliferation, and scar formation that are observed in adults are not seen. Numerous studies have reported the causes of fetal scarless cutaneous regeneration, including reduced expression of TGF-β1 and higher levels of hyaluronan in the extracellular matrix, from the viewpoints of molecular biology and cellular biology, but the mechanisms are not completely understood. Although a variety of substances that inhibit scar formation have been investigated, currently it is almost impossible for adult cutaneous wounds to heal completely without scars. Except for a few animal species, perfect regeneration after wounding can occur only during the gestation period. By strictly comparing the stages before and after the transition from the regeneration of skin to scarring, it will be possible to investigate the mechanisms of cutaneous regeneration.

元の言語English
ページ(範囲)101-108
ページ数8
ジャーナルKeio Journal of Medicine
61
発行部数4
DOI
出版物ステータスPublished - 2012 12

Fingerprint

Regeneration
Cicatrix
Skin
Wounds and Injuries
Hyaluronic Acid
Wound Healing
Extracellular Matrix
Cell Biology
Molecular Biology
Fetus
Pregnancy

ASJC Scopus subject areas

  • Medicine(all)

これを引用

@article{8ba2495f198c48f0b78561294b32819a,
title = "Fetal skin possesses the ability to regenerate completely: Complete regeneration of skin",
abstract = "Until a certain developmental stage, cutaneous wounds in mammalian fetuses heal rapidly without scars with complete regeneration of the skin. In the process of fetal wound healing, infammatory responses, granulation proliferation, and scar formation that are observed in adults are not seen. Numerous studies have reported the causes of fetal scarless cutaneous regeneration, including reduced expression of TGF-β1 and higher levels of hyaluronan in the extracellular matrix, from the viewpoints of molecular biology and cellular biology, but the mechanisms are not completely understood. Although a variety of substances that inhibit scar formation have been investigated, currently it is almost impossible for adult cutaneous wounds to heal completely without scars. Except for a few animal species, perfect regeneration after wounding can occur only during the gestation period. By strictly comparing the stages before and after the transition from the regeneration of skin to scarring, it will be possible to investigate the mechanisms of cutaneous regeneration.",
keywords = "Fetal, Healing, Regeneration, Wound",
author = "Kazuo Kishi and Keisuke Okabe and Ruka Shimizu and Yoshiaki Kubota",
year = "2012",
month = "12",
doi = "10.2302/kjm.2011-0002-IR",
language = "English",
volume = "61",
pages = "101--108",
journal = "Keio Journal of Medicine",
issn = "0022-9717",
publisher = "Keio University School of Medicine",
number = "4",

}

TY - JOUR

T1 - Fetal skin possesses the ability to regenerate completely

T2 - Complete regeneration of skin

AU - Kishi, Kazuo

AU - Okabe, Keisuke

AU - Shimizu, Ruka

AU - Kubota, Yoshiaki

PY - 2012/12

Y1 - 2012/12

N2 - Until a certain developmental stage, cutaneous wounds in mammalian fetuses heal rapidly without scars with complete regeneration of the skin. In the process of fetal wound healing, infammatory responses, granulation proliferation, and scar formation that are observed in adults are not seen. Numerous studies have reported the causes of fetal scarless cutaneous regeneration, including reduced expression of TGF-β1 and higher levels of hyaluronan in the extracellular matrix, from the viewpoints of molecular biology and cellular biology, but the mechanisms are not completely understood. Although a variety of substances that inhibit scar formation have been investigated, currently it is almost impossible for adult cutaneous wounds to heal completely without scars. Except for a few animal species, perfect regeneration after wounding can occur only during the gestation period. By strictly comparing the stages before and after the transition from the regeneration of skin to scarring, it will be possible to investigate the mechanisms of cutaneous regeneration.

AB - Until a certain developmental stage, cutaneous wounds in mammalian fetuses heal rapidly without scars with complete regeneration of the skin. In the process of fetal wound healing, infammatory responses, granulation proliferation, and scar formation that are observed in adults are not seen. Numerous studies have reported the causes of fetal scarless cutaneous regeneration, including reduced expression of TGF-β1 and higher levels of hyaluronan in the extracellular matrix, from the viewpoints of molecular biology and cellular biology, but the mechanisms are not completely understood. Although a variety of substances that inhibit scar formation have been investigated, currently it is almost impossible for adult cutaneous wounds to heal completely without scars. Except for a few animal species, perfect regeneration after wounding can occur only during the gestation period. By strictly comparing the stages before and after the transition from the regeneration of skin to scarring, it will be possible to investigate the mechanisms of cutaneous regeneration.

KW - Fetal

KW - Healing

KW - Regeneration

KW - Wound

UR - http://www.scopus.com/inward/record.url?scp=84874822215&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84874822215&partnerID=8YFLogxK

U2 - 10.2302/kjm.2011-0002-IR

DO - 10.2302/kjm.2011-0002-IR

M3 - Article

C2 - 23324304

AN - SCOPUS:84874822215

VL - 61

SP - 101

EP - 108

JO - Keio Journal of Medicine

JF - Keio Journal of Medicine

SN - 0022-9717

IS - 4

ER -