Fgf/MAPK signalling is a crucial positional cue in somite boundary formation

A. Sawada, M. Shinya, Y. J. Jiang, A. Kawakami, A. Kuroiwa, H. Takeda

研究成果: Article査読

223 被引用数 (Scopus)

抄録

The temporal and spatial regulation of somitogenesis requires a molecular oscillator, the segmentation clock. Through Notch signalling, the oscillation in cells is coordinated and translated into a cyclic wave of expression of hairy-related and other genes. The wave sweeps caudorostrally through the presomitic mesoderm (PSM) and finally arrests at the future segmentation point in the anterior PSM. By experimental manipulation and analyses in zebrafish somitogenesis mutants, we have found a novel component involved in this process. We report that the level of Fgf/MAPK activation (highest in the posterior PSM) serves as a positional cue within the PSM that regulates progression of the cyclic wave and thereby governs the positions of somite boundary formation.

本文言語English
ページ(範囲)4873-4880
ページ数8
ジャーナルDevelopment
128
23
出版ステータスPublished - 2001 12 27
外部発表はい

ASJC Scopus subject areas

  • Molecular Biology
  • Developmental Biology

フィンガープリント 「Fgf/MAPK signalling is a crucial positional cue in somite boundary formation」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル