Five New C-Methyl Flavonoids, the Potent Aldose Reductase Inhibitors from Matteuccia orientalis trev.

Purusotam Basnet, Shigetoshi Kadota, Koji Hase, Tsuneo Namba

研究成果: Article査読

37 被引用数 (Scopus)

抄録

Five new compounds, matteuorien, matteuorienin, and matteuorienate A (7), B (8), and C (9) were isolated together with five known compounds from the MeOH extract of the rhizome of Matteuccia orientalis trev. The structures of these compounds were determined by the use of spectroscopic methods including two dimensional (2D)-NMR experiments and chemical methods, except for the configuration at the C-3’” of matteuorienate A (7), B (8), and C (9). Among them, matteuorienate A, B, and C showed very strong aldose reductase inhibitory activity. A structure-activity relationship study showed that a carboxyl group played an important part in aldose reductase inhibitory activity in these three compounds.

本文言語English
ページ(範囲)1558-1564
ページ数7
ジャーナルChemical and Pharmaceutical Bulletin
43
9
DOI
出版ステータスPublished - 1995 1月 1
外部発表はい

ASJC Scopus subject areas

  • 化学 (全般)
  • 創薬

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