@inproceedings{2415c09c551b4919885930f6daee2215,
title = "Fixation-Free Evaluation of Cardiac Contractile Force by Human iPSC-Derived Cardiac Core-Shell Microfiber",
abstract = "We propose a core-shell microfiber-shaped cardiac tissue as a drug screening model with a fixation-free contractile force measurement system. The contractile force of the hiPSC-derived cardiac tissue can be calculated only with a motion analysis, thanks to a shell of hydrogel covering the cardiac tissue. Thus, the system can evaluate the behavior of the tissue in drug screenings without any specific equipment. We demonstrated drug screening tests with pharmaceuticals on our microfiber tissues, resulting in 102.7% increase of contractile force with isoproterenol and 56.3% decrease with propranolol. Our cardiac drug screening model can easily reproduce and evaluate cardiac disease models, and would contribute to the pathological research of unexplained cardiac diseases and pharmacokinetic testing. ",
keywords = "Cardiac Tissue, Hydrogel, Microfiber, Microfluidics, Tissue Engineering, iPSCs",
author = "Akari Masuda and Keisuke Fukada and Shun Itai and Yuta Kurashina and Shuichi Akizuki and Shugo Tohyama and Jun Fujita and Hiroaki Onoe",
note = "Funding Information: This work was partly supported by Grant-in Aid for Scientific Research (A) (19H01178), Japan Society for the Promotion of Science (JSPS), Japan. Publisher Copyright: {\textcopyright} 2022 IEEE.; 35th IEEE International Conference on Micro Electro Mechanical Systems Conference, MEMS 2022 ; Conference date: 09-01-2022 Through 13-01-2022",
year = "2022",
doi = "10.1109/MEMS51670.2022.9699631",
language = "English",
series = "IEEE Symposium on Mass Storage Systems and Technologies",
publisher = "IEEE Computer Society",
pages = "172--175",
booktitle = "35th IEEE International Conference on Micro Electro Mechanical Systems Conference, MEMS 2022",
}