FK506-associated limbic injury following umbilical cord blood transplantation

Y. Yoshida, H. Shimada, Takehiko Mori, H. Yoshihara, M. Takeoka, T. Takahashi

研究成果: Article査読

2 被引用数 (Scopus)

抄録

A 5-year-old girl with Ph-positive chronic myelogenous leukemia, who underwent umbilical cord blood transplantation, developed two episodes of electrical status epilepticus while receiving tacrolimus (FK506) then cyclosporin A (CsA), as treatment against graft-versus-host disease. MRI including diffusion weighted MR imaging of the brain revealed abnormalities in the hippocampus and posterior white matter following FK506 and CsA treatment, respectively. While posterior white matter injury has been described with both FK506 and CsA, no previous report describes hippocampal injury from either drug. The MRI changes in the hippocampus in our case suggest possible increased susceptibility to hippocampal injury with FK506.

本文言語English
ページ(範囲)523-525
ページ数3
ジャーナルBone Marrow Transplantation
32
5
DOI
出版ステータスPublished - 2003 9月

ASJC Scopus subject areas

  • 血液学
  • 移植

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