Flagella facilitate escape of Salmonella from oncotic macrophages

Gen Ichiro Sano, Yasunari Takada, Shinichi Goto, Kenta Maruyama, Yutaka Shindo, Kotaro Oka, Hidenori Matsui, Koichi Matsuo

研究成果: Article査読

39 被引用数 (Scopus)

抄録

The intracellular parasite Salmonella enterica serovar Typhimurium causes a typhoid-like systemic disease in mice. Whereas the survival of Salmonella in phagocytes is well understood, little has been documented about the exit of intracellular Salmonella from host cells. Here we report that in a population of infected macrophages Salmonella induces "oncosis," an irreversible progression to eukaryotic cell death characterized by swelling of the entire cell body. Oncotic macrophages (OnMφs) are terminal deoxynucleotidyltransferase-mediated dUTP-biotin nick end labeling negative and lack actin filaments (F-actin). The plasma membrane of OnMφs filled with bacilli remains impermeable, and intracellular Salmonella bacilli move vigorously using flagella. Eventually, intracellular Salmonella bacilli intermittently exit host cells in a flagellum-dependent manner. These results suggest that induction of macrophage oncosis and intracellular accumulation of flagellated bacilli constitute a strategy whereby Salmonella escapes from host macrophages.

本文言語English
ページ(範囲)8224-8232
ページ数9
ジャーナルJournal of Bacteriology
189
22
DOI
出版ステータスPublished - 2007 11

ASJC Scopus subject areas

  • 微生物学
  • 分子生物学

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