Flow cytometric analysis of surface antigens on human conjunctival epithelial cells

Tsutomu Fujihara, Tsutomu Takeuchi, Keiko Saito, Kazuo Tsubota

研究成果: Article査読

17 被引用数 (Scopus)

抄録

We analyzed the levels of expression of different surface adhesion molecules on normal human conjunctival epithelial cells with cytology and flow cytometry. The levels of β1 (CD29), VLA-1 (CD49a), VLA-2 (CD49b), and VLA-3 (CD49c) integrins were high, whereas those of VLA-5 (CD49e) and VLA-6 (CD49f) were faint, and that of VLA-4 (CD49d) was undetectable. Among the β2 integrins, the levels of Mac-1 (CD1 lb) and p 150.25 (CD 11 c) were positive, while LFA-1 (CD 11 a) was not detectable. HLA class I and class II were also expressed. However, CR2 (CD21), CD57, CD44 and ICAM-1 (CD54) were not detected. Our study suggests that these techniques may aid in identifying changes in the expression levels of various surface antigens on conjunctival epithelial cells that could occur in ocular surface disease.

本文言語English
ページ(範囲)103-109
ページ数7
ジャーナルOphthalmic research
29
2
DOI
出版ステータスPublished - 1997 1 1
外部発表はい

ASJC Scopus subject areas

  • 眼科学
  • 感覚系
  • 細胞および分子神経科学

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