Fluorinated diamond-like carbon as antithrombogenic coating for blood-contacting devices

Terumitsu Hasebe, Atsushi Shimada, Tetsuya Suzuki, Yoshiaki Matsuoka, Toshiya Saito, Satoshi Yohena, Aki Kamijo, Nobuyuki Shiraga, Mutsumi Higuchi, Kanako Kimura, Hirokuni Yoshimura, Sachio Kuribayashi

研究成果: Article査読

84 被引用数 (Scopus)

抄録

Diamond-like carbon (DLC) is being considered for widespread clinical use as a surface coating for cardiovascular devices. We synthesized fluorinated DLC (F-DLC) coatings in order to create a more Hydrophobic surface with improved antithrombogenicity and flexibility when compared with conventional DLC coatings by combining the inertness of DLC films with the advantage of fluorination, The purpose of this study was to evaluate the in vitro hemocompatibility and in vivo biocompatibility of the F-DLC coating for medical devices. The in vitro whole blood model confirmed that platelet loss was lower in the F-DLC group than in the noncoated group (SUS316L), which suggests the adhesion of a smaller number of platelets to F-DLC-coated materials. Furthermore, the biomarkers of mechanically induced platelet activation (beta-thromboglobulin) and activated coagulation (thrombin-antithrombin-three complex) were markedly reduced in the F-DLC-coated group. In vivo rat implant model studies revealed no excessive local and systemic inflammatory responses in the F-DLC group. The thickness of the fibrous tissue capsule surrounding the F-DLC-coated disk was almost equal to that of the noncoated SUS316L disk, which has the favorable biocompatibility for metallic implant materials. F-DLC coating thus appears to be a promising candidate for use as a coating material in blood-contacting devices.

本文言語English
ページ(範囲)86-94
ページ数9
ジャーナルJournal of Biomedical Materials Research - Part A
76
1
DOI
出版ステータスPublished - 2006 1

ASJC Scopus subject areas

  • セラミックおよび複合材料
  • 生体材料
  • 生体医工学
  • 金属および合金

フィンガープリント

「Fluorinated diamond-like carbon as antithrombogenic coating for blood-contacting devices」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル