Fluoroquinolones reduce carrageenan-induced edema in rats and the involvement of the glucocorticoid receptor system

Hiromi Ogino, Kaori Yamada, Mizuki Yuhara, Saori Tsuchida, Kayoko Maezawa, Junko Kizu, Seiji Hori

研究成果: Article査読

抄録

We studied the effect of fluoroquinolones (FQs) on carrageenan-induced edema in the rat footpad. Ciprofloxacin, gatifloxacin, sparfloxacin, norfloxacin, and enoxacin (s.c., 100 mg/kg), which have piperazinyl and/or cyclopropyl groups, inhibited carrageenan-induced edema, whereas levofloxacin, tosufloxacin, and pazufloxacin did not. The reduction of edema by ciprofloxacin, sparfloxacin, and enoxacin was abolished by pretreatment with mifepristone, an antagonist of the glucocorticoid receptor. These results suggest that FQs with piperazinyl and/or cyclopropyl groups can modify biological responses through enhancing the glucocorticoid-glucocorticoid receptor system.

本文言語English
ページ(範囲)113-117
ページ数5
ジャーナルJournal of Infection and Chemotherapy
15
2
DOI
出版ステータスPublished - 2009 4月

ASJC Scopus subject areas

  • 微生物学(医療)
  • 薬理学(医学)
  • 感染症

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