Focal adhesion kinase is not essential for in vitro and in vivo differentiation of ES cells

Dusko Ilic, Yasuhide Furuta, Toshio Suda, Tadao Atsumi, Jiro Fujimoto, Yoji Ikawa, Tadashi Yamamoto, Shinichi Aizawa

研究成果: Article

55 被引用数 (Scopus)

抄録

Focal adhesion kinase, FAK, is a unique protein tyrosine kinase found in cellular focal adhesions. It is widely expressed and highly phosphorylated during embryogenesis. To examine the function of FAK in cell differentiation, we made FAK-deficient embryonic stem (ES) cells by homologous recombination. However, FAK deficiency did not interfere with differentiation of the ES cells into cells of three germ layers when implanted subcutaneously into nude mice or when treated with retinoic acid in vitro, nor was there any evidence of defects in hematopoiesis in vitro.

本文言語English
ページ(範囲)300-309
ページ数10
ジャーナルBiochemical and Biophysical Research Communications
209
1
DOI
出版ステータスPublished - 1995 4 6

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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