Follicular helper T cells in the pathogenesis of IgG4-related disease

Mitsuhiro Akiyama, Katsuya Suzuki, Hidekata Yasuoka, Yuko Kaneko, Kunihiro Yamaoka, Tsutomu Takeuchi

研究成果: Review article

24 引用 (Scopus)

抜粋

IgG4-related disease (IgG4-RD) is a recently recognized disease entity characterized by high serum IgG4 concentrations and infiltration of IgG4+ plasma cells with hyperplastic ectopic germinal centres at affected sites. Although the underlying immune mechanism of this disease remains unclear, T cells are abundantly present at affected sites and key players in IgG4-RD pathogenesis. The role of T cell subsets has been investigated thoroughly in this disease. Recent advances in this field have clarified the importance of T follicular helper cells. In this review, we describe the role of T follicular helper cells in the disease process of IgG4-RD, in particular, for IgG4 class-switching, plasmablast and plasma cell differentiation, and germinal centre formation.

元の言語English
記事番号kex171
ページ(範囲)236-245
ページ数10
ジャーナルRheumatology (United Kingdom)
57
発行部数2
DOI
出版物ステータスPublished - 2018 2 1

    フィンガープリント

ASJC Scopus subject areas

  • Rheumatology
  • Pharmacology (medical)

これを引用