抄録
IgG4-related disease (IgG4-RD) is a recently recognized disease entity characterized by high serum IgG4 concentrations and infiltration of IgG4+ plasma cells with hyperplastic ectopic germinal centres at affected sites. Although the underlying immune mechanism of this disease remains unclear, T cells are abundantly present at affected sites and key players in IgG4-RD pathogenesis. The role of T cell subsets has been investigated thoroughly in this disease. Recent advances in this field have clarified the importance of T follicular helper cells. In this review, we describe the role of T follicular helper cells in the disease process of IgG4-RD, in particular, for IgG4 class-switching, plasmablast and plasma cell differentiation, and germinal centre formation.
| 元の言語 | English |
|---|---|
| 記事番号 | kex171 |
| ページ（範囲） | 236-245 |
| ページ数 | 10 |
| ジャーナル | Rheumatology (United Kingdom) |
| 巻 | 57 |
| 発行部数 | 2 |
| DOI | |
| 出版物ステータス | Published - 2018 2 1 |
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ASJC Scopus subject areas
- Rheumatology
- Pharmacology (medical)
これを引用
Follicular helper T cells in the pathogenesis of IgG4-related disease. / Akiyama, Mitsuhiro; Suzuki, Katsuya; Yasuoka, Hidekata; Kaneko, Yuko; Yamaoka, Kunihiro; Takeuchi, Tsutomu.
：: Rheumatology (United Kingdom), 巻 57, 番号 2, kex171, 01.02.2018, p. 236-245.研究成果: Review article
}
TY - JOUR
T1 - Follicular helper T cells in the pathogenesis of IgG4-related disease
AU - Akiyama, Mitsuhiro
AU - Suzuki, Katsuya
AU - Yasuoka, Hidekata
AU - Kaneko, Yuko
AU - Yamaoka, Kunihiro
AU - Takeuchi, Tsutomu
PY - 2018/2/1
Y1 - 2018/2/1
N2 - IgG4-related disease (IgG4-RD) is a recently recognized disease entity characterized by high serum IgG4 concentrations and infiltration of IgG4+ plasma cells with hyperplastic ectopic germinal centres at affected sites. Although the underlying immune mechanism of this disease remains unclear, T cells are abundantly present at affected sites and key players in IgG4-RD pathogenesis. The role of T cell subsets has been investigated thoroughly in this disease. Recent advances in this field have clarified the importance of T follicular helper cells. In this review, we describe the role of T follicular helper cells in the disease process of IgG4-RD, in particular, for IgG4 class-switching, plasmablast and plasma cell differentiation, and germinal centre formation.
AB - IgG4-related disease (IgG4-RD) is a recently recognized disease entity characterized by high serum IgG4 concentrations and infiltration of IgG4+ plasma cells with hyperplastic ectopic germinal centres at affected sites. Although the underlying immune mechanism of this disease remains unclear, T cells are abundantly present at affected sites and key players in IgG4-RD pathogenesis. The role of T cell subsets has been investigated thoroughly in this disease. Recent advances in this field have clarified the importance of T follicular helper cells. In this review, we describe the role of T follicular helper cells in the disease process of IgG4-RD, in particular, for IgG4 class-switching, plasmablast and plasma cell differentiation, and germinal centre formation.
KW - Germinal centre
KW - IgG4-related disease
KW - Interleukin-21
KW - Interleukin-4
KW - Pathogenesis
KW - Plasmablast
KW - Somatic hypermutation
KW - T follicular helper cell
KW - T lymphocyte
UR - http://www.scopus.com/inward/record.url?scp=85041503887&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85041503887&partnerID=8YFLogxK
U2 - 10.1093/rheumatology/kex171
DO - 10.1093/rheumatology/kex171
M3 - Review article
C2 - 28460058
AN - SCOPUS:85041503887
VL - 57
SP - 236
EP - 245
JO - Rheumatology (United Kingdom)
JF - Rheumatology (United Kingdom)
SN - 1462-0324
IS - 2
M1 - kex171
ER -