@article{89ac4e3dea2d4461a9be7c33fbc094f8,
title = "Follicular helper T cells in the pathogenesis of IgG4-related disease",
abstract = "IgG4-related disease (IgG4-RD) is a recently recognized disease entity characterized by high serum IgG4 concentrations and infiltration of IgG4+ plasma cells with hyperplastic ectopic germinal centres at affected sites. Although the underlying immune mechanism of this disease remains unclear, T cells are abundantly present at affected sites and key players in IgG4-RD pathogenesis. The role of T cell subsets has been investigated thoroughly in this disease. Recent advances in this field have clarified the importance of T follicular helper cells. In this review, we describe the role of T follicular helper cells in the disease process of IgG4-RD, in particular, for IgG4 class-switching, plasmablast and plasma cell differentiation, and germinal centre formation.",
keywords = "Germinal centre, IgG4-related disease, Interleukin-21, Interleukin-4, Pathogenesis, Plasmablast, Somatic hypermutation, T follicular helper cell, T lymphocyte",
author = "Mitsuhiro Akiyama and Katsuya Suzuki and Hidekata Yasuoka and Yuko Kaneko and Kunihiro Yamaoka and Tsutomu Takeuchi",
note = "Funding Information: Disclosure statement: Y.T. has received consultant fees from Pfizer, Chugai Pharma, Mitsubishi-Tanabe Pharma and AbbVie, received honoraria from Pfizer, Chugai Pharma, Mitsubishi-Tanabe Pharma, Bristol-Myers Squibb, Takeda Industrial Pharma, GlaxoSmithkline, Nippon Shinyaku, Eli Lilly, Janssen Pharma, Eisai Pharma, Astellas Pharma and Actelion Pharmaceuticals and received research support from Chugai Pharma and Mitsubishi-Tanabe Pharma. T.T has received consulting fees, speaking fees and/or honoraria from Pfizer Japan, Publisher Copyright: {\textcopyright} The Author 2017. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. Copyright: Copyright 2018 Elsevier B.V., All rights reserved.",
year = "2018",
month = feb,
day = "1",
doi = "10.1093/rheumatology/kex171",
language = "English",
volume = "57",
pages = "236--245",
journal = "Rheumatology and Rehabilitation",
issn = "1462-0324",
publisher = "Oxford University Press",
number = "2",
}