@article{c3188c30cfcb466fa8cef8ca6d7e9a46,
title = "Formal synthesis of englerin A utilizing regio- and diastereoselective [4+3] cycloaddition",
abstract = "Englerin A, a guaiane sesquiterpene isolated from Phyllanthus engleri, showed highly potent and selective growth inhibitory activities against renal cancer cell lines. We synthesized the key tricyclic intermediate from commercially available 2,2-dimethyl-1,3-dioxan-5-one via regio- and diastereoselective [4+3] cycloaddition between the formyl enol silyl ether and the disubstituted furan, in 4.8% total yield over 10 steps.",
author = "Shuichi Hagihara and Kengo Hanaya and Takeshi Sugai and Mitsuru Shoji",
note = "Funding Information: This work was supported by Platform for Drug Discovery, Informatics and Structural Life Science (No. 12759017) from the Ministry of Education, Culture, Sports, Science and Technology, Japan. Publisher Copyright: {\textcopyright} 2018 Japan Antibiotics Research Association All rights reserved.",
year = "2018",
month = feb,
day = "1",
doi = "10.1038/ja.2017.91",
language = "English",
volume = "71",
pages = "257--262",
journal = "Journal of Antibiotics",
issn = "0021-8820",
publisher = "Japan Antibiotics Research Association",
number = "2",
}
