Formal synthesis of englerin A utilizing regio- and diastereoselective [4+3] cycloaddition

Shuichi Hagihara, Kengo Hanaya, Takeshi Sugai, Mitsuru Shoji

研究成果: Article査読

5 被引用数 (Scopus)

抄録

Englerin A, a guaiane sesquiterpene isolated from Phyllanthus engleri, showed highly potent and selective growth inhibitory activities against renal cancer cell lines. We synthesized the key tricyclic intermediate from commercially available 2,2-dimethyl-1,3-dioxan-5-one via regio- and diastereoselective [4+3] cycloaddition between the formyl enol silyl ether and the disubstituted furan, in 4.8% total yield over 10 steps.

本文言語English
ページ(範囲)257-262
ページ数6
ジャーナルJournal of Antibiotics
71
2
DOI
出版ステータスPublished - 2018 2 1

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

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