Formation of free radicals from steroid hormones: Possible significance in environmental carcinogenesis

Masahiko Kodama, F. Inoue, H. Saito, T. Oda, Y. Sato

研究成果: Article

8 引用 (Scopus)

抄録

In order to clarify the mechanism of environmental carcinogenesis, steroid hormones were checked for formation of free radicals and active oxygen species. In alkaline DMSO in vitro, glucocorticoids, progestines, androgens and estrogens exhibited distinct ESR signals with characteristic hyperfine structures. Accumulated data on a great number of steroid derivatives suggest that an unpaired electron is localized at position 20 in the case of glucocorticoids, whereas it is at position 3 in other steroid hormones. Since experimental conditions include oxygenation reactions and more or less reflect enzymatic reactivity, the results obtained suggest further study on the physiological formation of free radicals from steroid hormone is warranted. Although detection of the free radicals of steroid hormones in several enzyme systems was limited to estrogens, evidence suggests that glucocorticoids as well as androgens may also share the physiological formation of free radicals. The production of active oxygen species was confirmed in certain cases.

元の言語English
ページ(範囲)439-444
ページ数6
ジャーナルAnticancer Research
17
発行部数1 A
出版物ステータスPublished - 1997

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Free Radicals
Carcinogenesis
Steroids
Hormones
Glucocorticoids
Androgens
Reactive Oxygen Species
Estrogens
Dimethyl Sulfoxide
Electrons
Enzymes

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

これを引用

Kodama, M., Inoue, F., Saito, H., Oda, T., & Sato, Y. (1997). Formation of free radicals from steroid hormones: Possible significance in environmental carcinogenesis. Anticancer Research, 17(1 A), 439-444.

Formation of free radicals from steroid hormones : Possible significance in environmental carcinogenesis. / Kodama, Masahiko; Inoue, F.; Saito, H.; Oda, T.; Sato, Y.

:: Anticancer Research, 巻 17, 番号 1 A, 1997, p. 439-444.

研究成果: Article

Kodama, M, Inoue, F, Saito, H, Oda, T & Sato, Y 1997, 'Formation of free radicals from steroid hormones: Possible significance in environmental carcinogenesis', Anticancer Research, 巻. 17, 番号 1 A, pp. 439-444.
Kodama, Masahiko ; Inoue, F. ; Saito, H. ; Oda, T. ; Sato, Y. / Formation of free radicals from steroid hormones : Possible significance in environmental carcinogenesis. :: Anticancer Research. 1997 ; 巻 17, 番号 1 A. pp. 439-444.
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