FOXD1 expression is associated with poor prognosis in non-small cell lung cancer

Sohei Nakayama, Kenzo Soejima, Hiroyuki Yasuda, Satoshi Yoda, Ryosuke Satomi, Shinnosuke Ikemura, Hideki Terai, Takashi Sato, Norihiro Yamaguchi, Junko Hamamoto, Daisuke Arai, Kota Ishioka, Keiko Ohgino, Katsuhiko Naoki, Tomoko Betsuyaku

研究成果: Article査読

23 被引用数 (Scopus)

抄録

Aim: Clinical microarray datasets were analyzed to search for new therapeutic targets and prognostic markers of non-small cell lung cancer (NSCLC).

Materials and Methods: Microarray datasets from 90 lung cancer specimens, were analyzed with focus on the FOXD1 gene. Levels of FOXD1 mRNA were assessed in lung cancer cell lines and these levels were correlated with survival.

Results: FOXD1-knockdown led to suppression of cell proliferation. Moreover, patients with high FOXD1 expression survived for a significantly shorter time than those with low FOXD1 expression.

Conclusion: The expression status of FOXD1 is a novel prognostic factor and may lead to new treatment strategies for NSCLC.

本文言語English
ページ(範囲)261-268
ページ数8
ジャーナルAnticancer research
35
1
出版ステータスPublished - 2015 1 1

ASJC Scopus subject areas

  • 腫瘍学
  • 癌研究

フィンガープリント

「FOXD1 expression is associated with poor prognosis in non-small cell lung cancer」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル