Free radicals in helicobacter pylori infection

Hidekazu Suzuki, Toshihiro Nishizawa, Hitoshi Tsugawa, Toshifumi Hibi

研究成果: Chapter

1 引用 (Scopus)

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Helicobacter pylori infection, which is the main cause of gastritis, peptic ulcer disease and gastric cancer, is associated with infiltration of the gastric mucosa by neutrophils, macrophages, and B and T lymphocytes. However, this immune and inflammatory response cannot completely control the bacterial infection, and leaves the host prone to complications resulting from persistent inflammation. As a result, H. pylori infection may cause chronic inflammation, accumulation of reactive oxygen species, and oxidative DNA damage in the gastric mucosa. The H. pylori bacterial effector proteins are transported into the gastric host cells via the type IV secretory system, and regulate intracellular signal transduction. This mechanism provides novel insight into how H. pylori survives in the acidic environment of the human stomach. In cases with persistent gastric infection, the chronic gastritis may remain asymptomatic or may evolve into more severe diseases, such as peptic ulcer disease and chronic atrophic gastritis. In addition, infection with H. pylori increases the risk of development of gastric cancer and mucosa-associated lymphoid tissue lymphoma. This review focuses on the oxidative mechanisms involved in the bacterial and host-mucosal responses during colonization of the gastric mucosa by H. pylori.

元の言語English
ホスト出版物のタイトルFree Radical Biology in Digestive Diseases
編集者Yuji Naito, Toshikazu Yoshikawa, Makoto Suematsu
ページ111-120
ページ数10
DOI
出版物ステータスPublished - 2010 12 1

出版物シリーズ

名前Frontiers of Gastrointestinal Research
29
ISSN(印刷物)0302-0665

ASJC Scopus subject areas

  • Gastroenterology

フィンガープリント Free radicals in helicobacter pylori infection' の研究トピックを掘り下げます。これらはともに一意のフィンガープリントを構成します。

  • これを引用

    Suzuki, H., Nishizawa, T., Tsugawa, H., & Hibi, T. (2010). Free radicals in helicobacter pylori infection. : Y. Naito, T. Yoshikawa, & M. Suematsu (版), Free Radical Biology in Digestive Diseases (pp. 111-120). (Frontiers of Gastrointestinal Research; 巻数 29). https://doi.org/10.1159/00031997910