DnaA protein is an initiator for chromosomal DNA replication in E. coli. We have examined the function of the protein to answer the following four questions; How DnaA protein is inactivated after DNA replication for the suppression of re-initiation? How DnaA protein is activated for the initiation of DNA replication? Does DnaA protein have functions other than that for DNA replication? Is DnaA protein is a good target for new antibiotics? In this review, I summarize our recent studies for these questions.
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