TY - JOUR
T1 - Function of RNA-binding protein Musashi-1 in stem cells
AU - Okano, Hideyuki
AU - Kawahara, Hironori
AU - Toriya, Masako
AU - Nakao, Keio
AU - Shibata, Shinsuke
AU - Imai, Takao
N1 - Funding Information:
We would like to thank Drs. Makoto Nakamura, Craig Montell, Shin-ichi Sakakibara, and Masataka Okabe for their contributions to the original research on Musashi and the members of the Okano Laboratory for their valuable discussions. This work was supported by grants from the Japanese Ministry of Education, Sports and Culture of Japan to HO, and a grant from the 21st Century COE program of the Ministry of Education, Science and Culture of Japan to Keio University.
PY - 2005/6/10
Y1 - 2005/6/10
N2 - Musashi is an evolutionarily conserved family of RNA-binding proteins that is preferentially expressed in the nervous system. The first member of the Musashi family was identified in Drosophila. This protein plays an essential role in regulating the asymmetric cell division of ectodermal precursor cells known as sensory organ precursor cells through the translational regulation of target mRNA. In the CNS of Drosophila larvae, however, Musashi is expressed in proliferating neuroblasts and likely has a different function. Its probable mammalian homologue, Musashi-1, is a neural RNA-binding protein that is strongly expressed in fetal and adult neural stem cells (NSCs). Mammalian Musashi-1 augments Notch signaling through the translational repression of its target mRNA, m-Numb, thereby contributing to the self-renewal of NSCs. In addition to its functions in NSCs, the role of mammalian Musashi-1 protein in epithelial stem cells, including intestinal and mammary gland stem cells, is attracting increasing interest.
AB - Musashi is an evolutionarily conserved family of RNA-binding proteins that is preferentially expressed in the nervous system. The first member of the Musashi family was identified in Drosophila. This protein plays an essential role in regulating the asymmetric cell division of ectodermal precursor cells known as sensory organ precursor cells through the translational regulation of target mRNA. In the CNS of Drosophila larvae, however, Musashi is expressed in proliferating neuroblasts and likely has a different function. Its probable mammalian homologue, Musashi-1, is a neural RNA-binding protein that is strongly expressed in fetal and adult neural stem cells (NSCs). Mammalian Musashi-1 augments Notch signaling through the translational repression of its target mRNA, m-Numb, thereby contributing to the self-renewal of NSCs. In addition to its functions in NSCs, the role of mammalian Musashi-1 protein in epithelial stem cells, including intestinal and mammary gland stem cells, is attracting increasing interest.
KW - Intestinal stem cell
KW - Mammary gland stem cell
KW - Musashi
KW - Neural stem cell
KW - Notch signaling
KW - Numb
KW - Translational regulation
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U2 - 10.1016/j.yexcr.2005.02.021
DO - 10.1016/j.yexcr.2005.02.021
M3 - Review article
C2 - 15925591
AN - SCOPUS:19544393523
VL - 306
SP - 349
EP - 356
JO - Experimental Cell Research
JF - Experimental Cell Research
SN - 0014-4827
IS - 2
ER -