Functional comparison of transactivation by human retrovirus rev and rex genes

H. Sakai, H. Siomi, H. Shida, R. Shibata, T. Kiyomasu, A. Adachi

研究成果: Article査読

42 被引用数 (Scopus)

抄録

The effect of rev-responsive element deletion on human immunodeficiency virus type 1 (HIV-1) and type 2 (HIV-2) gene expression was examined. The phenotypes of HIV-1 and HIV-2 provirus DNAs lacking the rev-responsive element, as determined by transfection experiments, were indistinguishable from those of virus DNAs carrying rev gene mutations. By using rev-responsive elements derived from these two viruses, we developed two monitoring systems to evaluate the functionality of HIV-1 rev, HIV-2 rev, and human T-lymphotropic virus type I rex. In both systems, HIV-1 rev and human T-lymphotropic virus type I rex transactivated HIV-2 very efficiently. On the contrary, HIV-2 rev and human T-lymphotropic virus type I rex were poor activators of HIV-1. No functional replacement of rex by HIV-2 rev was observed.

本文言語English
ページ(範囲)5833-5839
ページ数7
ジャーナルJournal of Virology
64
12
出版ステータスPublished - 1990 1月 1
外部発表はい

ASJC Scopus subject areas

  • 微生物学
  • 免疫学
  • 昆虫科学
  • ウイルス学

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