Functional dynamics of cell surface membrane proteins

Noritaka Nishida, Masanori Osawa, Koh Takeuchi, Shunsuke Imai, Pavlos Stampoulis, Yutaka Kofuku, Takumi Ueda, Ichio Shimada

研究成果: Article査読

9 被引用数 (Scopus)

抄録

Cell surface receptors are integral membrane proteins that receive external stimuli, and transmit signals across plasma membranes. In the conventional view of receptor activation, ligand binding to the extracellular side of the receptor induces conformational changes, which convert the structure of the receptor into an active conformation. However, recent NMR studies of cell surface membrane proteins have revealed that their structures are more dynamic than previously envisioned, and they fluctuate between multiple conformations in an equilibrium on various timescales. In addition, NMR analyses, along with biochemical and cell biological experiments indicated that such dynamical properties are critical for the proper functions of the receptors. In this review, we will describe several NMR studies that revealed direct linkage between the structural dynamics and the functions of the cell surface membrane proteins, such as G-protein coupled receptors (GPCRs), ion channels, membrane transporters, and cell adhesion molecules.

本文言語English
ページ(範囲)86-96
ページ数11
ジャーナルJournal of Magnetic Resonance
241
1
DOI
出版ステータスPublished - 2014 4月
外部発表はい

ASJC Scopus subject areas

  • 生物理学
  • 生化学
  • 核物理学および高エネルギー物理学
  • 凝縮系物理学

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