Functional dynamics of cell surface membrane proteins

Noritaka Nishida, Masanori Osawa, Koh Takeuchi, Shunsuke Imai, Pavlos Stampoulis, Yutaka Kofuku, Takumi Ueda, Ichio Shimada

研究成果: Article

4 引用 (Scopus)

抄録

Cell surface receptors are integral membrane proteins that receive external stimuli, and transmit signals across plasma membranes. In the conventional view of receptor activation, ligand binding to the extracellular side of the receptor induces conformational changes, which convert the structure of the receptor into an active conformation. However, recent NMR studies of cell surface membrane proteins have revealed that their structures are more dynamic than previously envisioned, and they fluctuate between multiple conformations in an equilibrium on various timescales. In addition, NMR analyses, along with biochemical and cell biological experiments indicated that such dynamical properties are critical for the proper functions of the receptors. In this review, we will describe several NMR studies that revealed direct linkage between the structural dynamics and the functions of the cell surface membrane proteins, such as G-protein coupled receptors (GPCRs), ion channels, membrane transporters, and cell adhesion molecules.

元の言語English
ページ(範囲)86-96
ページ数11
ジャーナルJournal of Magnetic Resonance
241
発行部数1
DOI
出版物ステータスPublished - 2014
外部発表Yes

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Membrane Proteins
Nuclear magnetic resonance
membranes
proteins
Conformations
cells
Membrane Transport Proteins
Structural dynamics
Cell Adhesion Molecules
Cell Surface Receptors
Cell membranes
G-Protein-Coupled Receptors
Ion Channels
nuclear magnetic resonance
Chemical activation
Ligands
transporter
dynamic structural analysis
linkages
stimuli

ASJC Scopus subject areas

  • Nuclear and High Energy Physics
  • Biochemistry
  • Biophysics
  • Condensed Matter Physics

これを引用

Nishida, N., Osawa, M., Takeuchi, K., Imai, S., Stampoulis, P., Kofuku, Y., ... Shimada, I. (2014). Functional dynamics of cell surface membrane proteins. Journal of Magnetic Resonance, 241(1), 86-96. https://doi.org/10.1016/j.jmr.2013.11.007

Functional dynamics of cell surface membrane proteins. / Nishida, Noritaka; Osawa, Masanori; Takeuchi, Koh; Imai, Shunsuke; Stampoulis, Pavlos; Kofuku, Yutaka; Ueda, Takumi; Shimada, Ichio.

:: Journal of Magnetic Resonance, 巻 241, 番号 1, 2014, p. 86-96.

研究成果: Article

Nishida, N, Osawa, M, Takeuchi, K, Imai, S, Stampoulis, P, Kofuku, Y, Ueda, T & Shimada, I 2014, 'Functional dynamics of cell surface membrane proteins', Journal of Magnetic Resonance, 巻. 241, 番号 1, pp. 86-96. https://doi.org/10.1016/j.jmr.2013.11.007
Nishida N, Osawa M, Takeuchi K, Imai S, Stampoulis P, Kofuku Y その他. Functional dynamics of cell surface membrane proteins. Journal of Magnetic Resonance. 2014;241(1):86-96. https://doi.org/10.1016/j.jmr.2013.11.007
Nishida, Noritaka ; Osawa, Masanori ; Takeuchi, Koh ; Imai, Shunsuke ; Stampoulis, Pavlos ; Kofuku, Yutaka ; Ueda, Takumi ; Shimada, Ichio. / Functional dynamics of cell surface membrane proteins. :: Journal of Magnetic Resonance. 2014 ; 巻 241, 番号 1. pp. 86-96.
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