Functional dynamics of proteins revealed by solution NMR

Masanori Osawa, Koh Takeuchi, Takumi Ueda, Noritaka Nishida, Ichio Shimada

研究成果: Review article査読

31 被引用数 (Scopus)

抄録

Solution NMR spectroscopy can analyze the dynamics of proteins on a wide range of timescales, from picoseconds to even days, in a site-specific manner, and thus its results are complementary to the detailed but largely static structural information obtained by X-ray crystallography. We review recent progresses in a variety of NMR techniques, including relaxation dispersion and paramagnetic relaxation enhancement (PRE), that permit the observation of the low-populated states, which had been 'invisible' with other techniques. In addition, we review how NMR spectroscopy can be used to elucidate functionally relevant protein dynamics.

本文言語English
ページ(範囲)660-669
ページ数10
ジャーナルCurrent Opinion in Structural Biology
22
5
DOI
出版ステータスPublished - 2012 10
外部発表はい

ASJC Scopus subject areas

  • 構造生物学
  • 分子生物学

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