Functional lacrimal gland regeneration by transplantation of a bioengineered organ germ

Masatoshi Hirayama, Miho Ogawa, Masamitsu Oshima, Yurie Sekine, Kentaro Ishida, Kentaro Yamashita, Kazutaka Ikeda, Shigeto Shimmura, Tetsuya Kawakita, Kazuo Tsubota, Takashi Tsuji

研究成果: Article

92 引用 (Scopus)

抄録

The lacrimal gland has a multifaceted role in maintaining a homeostatic microenvironment for a healthy ocular surface via tear secretion. Dry-eye disease, which is caused by lacrimal gland dysfunction, is one of the most prevalent eye diseases that cause corneal epithelial damage and results in significant loss of vision and a reduction in the quality of life. Here we demonstrate orthotopic transplantation of bioengineered lacrimal gland germs into adult mice with an extra-orbital lacrimal gland defect, a mouse model that mimics the corneal epithelial damage caused by lacrimal gland dysfunction. The bioengineered lacrimal gland germs and harderian gland germs both develop in vivo and achieve sufficient physiological functionality, including tear production in response to nervous stimulation and ocular surface protection. This study demonstrates the potential for bioengineered organ replacement to functionally restore the lacrimal gland.

元の言語English
記事番号2497
ジャーナルNature Communications
4
DOI
出版物ステータスPublished - 2013

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transplantation
Lacrimal Apparatus
glands
regeneration
organs
Regeneration
Transplantation
eye diseases
Eye Diseases
Defects
Tears
mice
Harderian Gland
damage
secretions
stimulation
Quality of Life
orbitals
causes
defects

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Chemistry(all)
  • Physics and Astronomy(all)

これを引用

Hirayama, M., Ogawa, M., Oshima, M., Sekine, Y., Ishida, K., Yamashita, K., ... Tsuji, T. (2013). Functional lacrimal gland regeneration by transplantation of a bioengineered organ germ. Nature Communications, 4, [2497]. https://doi.org/10.1038/ncomms3497

Functional lacrimal gland regeneration by transplantation of a bioengineered organ germ. / Hirayama, Masatoshi; Ogawa, Miho; Oshima, Masamitsu; Sekine, Yurie; Ishida, Kentaro; Yamashita, Kentaro; Ikeda, Kazutaka; Shimmura, Shigeto; Kawakita, Tetsuya; Tsubota, Kazuo; Tsuji, Takashi.

:: Nature Communications, 巻 4, 2497, 2013.

研究成果: Article

Hirayama, M, Ogawa, M, Oshima, M, Sekine, Y, Ishida, K, Yamashita, K, Ikeda, K, Shimmura, S, Kawakita, T, Tsubota, K & Tsuji, T 2013, 'Functional lacrimal gland regeneration by transplantation of a bioengineered organ germ', Nature Communications, 巻. 4, 2497. https://doi.org/10.1038/ncomms3497
Hirayama, Masatoshi ; Ogawa, Miho ; Oshima, Masamitsu ; Sekine, Yurie ; Ishida, Kentaro ; Yamashita, Kentaro ; Ikeda, Kazutaka ; Shimmura, Shigeto ; Kawakita, Tetsuya ; Tsubota, Kazuo ; Tsuji, Takashi. / Functional lacrimal gland regeneration by transplantation of a bioengineered organ germ. :: Nature Communications. 2013 ; 巻 4.
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