Functional recovery after spinal cord injury in mice through activation of microglia and dendritic cells after IL-12 administration

Masae Yaguchi, Shigeki Ohta, Yoshiaki Toyama, Yutaka Kawakami, Masahiro Toda

研究成果: Article査読

40 被引用数 (Scopus)

抄録

We have previously reported that the transplantation of dendritic cells (DCs) brings about functional recovery after spinal cord injury in mice through the activation of endogenous microglia/macrophages and neural stem/progenitor cells. In this study, the effect of interleukin-12 (IL-12), which is secreted from DCs, was evaluated for the treatment of spinal cord injury in mice. Administration of IL-12 into the injured site significantly increased the number of activated microglia/macrophages and DCs as well as the expression of brain-derived neurotrophic factor surrounding the lesion site. Immunohistochemical analyses showed that de novo neurogenesis and remyelination were induced by IL-12 treatment. Furthermore, an open field test using Basso-Beattie-Brenham scoring revealed a significant improvement of locomotor function in mice treated with IL-12. These results suggest that IL-12 administration into the injured spinal cord results in a functional recovery through the activation of microglia/macrophages and DCs.

本文言語English
ページ(範囲)1972-1980
ページ数9
ジャーナルJournal of neuroscience research
86
9
DOI
出版ステータスPublished - 2008 7月 1

ASJC Scopus subject areas

  • 細胞および分子神経科学

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