Functional Recovery from Neural Stem/Progenitor Cell Transplantation Combined with Treadmill Training in Mice with Chronic Spinal Cord Injury

Syoichi Tashiro, Soraya Nishimura, Hiroki Iwai, Keiko Sugai, Liang Zhang, Munehisa Shinozaki, Akio Iwanami, Yoshiaki Toyama, Meigen Liu, Hideyuki Okano, Masaya Nakamura

研究成果: Article査読

43 被引用数 (Scopus)

抄録

Most studies targeting chronic spinal cord injury (SCI) have concluded that neural stem/progenitor cell (NS/PC) transplantation exerts only a subclinical recovery; this in contrast to its remarkable effect on acute and subacute SCI. To determine whether the addition of rehabilitative intervention enhances the effect of NS/PC transplantation for chronic SCI, we used thoracic SCI mouse models to compare manifestations secondary to both transplantation and treadmill training, and the two therapies combined, with a control group. Significant locomotor recovery in comparison with the control group was only achieved in the combined therapy group. Further investigation revealed that NS/PC transplantation improved spinal conductivity and central pattern generator activity, and that treadmill training promoted the appropriate inhibitory motor control. The combined therapy enhanced these independent effects of each single therapy, and facilitated neuronal differentiation of transplanted cells and maturation of central pattern generator activity synergistically. Our data suggest that rehabilitative treatment represents a therapeutic option for locomotor recovery after NS/PC transplantation, even in chronic SCI.

本文言語English
論文番号30898
ジャーナルScientific reports
6
DOI
出版ステータスPublished - 2016 8 3

ASJC Scopus subject areas

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