Functional Specializations of Human Epidermal Langerhans Cells and CD14+ Dermal Dendritic Cells

Eynav Klechevsky, Rimpei Morita, Maochang Liu, Yanying Cao, Sebastien Coquery, Lu Ann Thompson-Snipes, Francine Briere, Damien Chaussabel, Gerard Zurawski, A. Karolina Palucka, Yoram Reiter, Jacques Banchereau, Hideki Ueno

研究成果: Article

415 引用 (Scopus)

抜粋

Little is known about the functional differences between the human skin myeloid dendritic cell (DC) subsets, epidermal CD207+ Langerhans cells (LCs) and dermal CD14+ DCs. We showed that CD14+ DCs primed CD4+ T cells into cells that induce naive B cells to switch isotype and become plasma cells. In contrast, LCs preferentially induced the differentiation of CD4+ T cells secreting T helper 2 (Th2) cell cytokines and were efficient at priming and crosspriming naive CD8+ T cells. A third DC population, CD14-CD207-CD1a+ DC, which resides in the dermis, could activate CD8+ T cells better than CD14+ DCs but less efficiently than LCs. Thus, the human skin displays three DC subsets, two of which, i.e., CD14+ DCs and LCs, display functional specializations, the preferential activation of humoral and cellular immunity, respectively.

元の言語English
ページ(範囲)497-510
ページ数14
ジャーナルImmunity
29
発行部数3
DOI
出版物ステータスPublished - 2008 9 19

    フィンガープリント

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases

これを引用

Klechevsky, E., Morita, R., Liu, M., Cao, Y., Coquery, S., Thompson-Snipes, L. A., Briere, F., Chaussabel, D., Zurawski, G., Palucka, A. K., Reiter, Y., Banchereau, J., & Ueno, H. (2008). Functional Specializations of Human Epidermal Langerhans Cells and CD14+ Dermal Dendritic Cells. Immunity, 29(3), 497-510. https://doi.org/10.1016/j.immuni.2008.07.013