Functionalized aryl-β-C-glycoside synthesis by Barbier-type reaction using 2,4,6-triisopropylphenyllithium

Kiyomi Ohba, Yuichi Koga, Sumihiro Nomura, Masaya Nakata

研究成果: Article査読

11 被引用数 (Scopus)

抄録

We developed an efficient synthetic route for functionalized aryl-β-C-glycosides, which are difficult to prepare by conventional methods. An aryl halide having an ester, cyano, or carbonyl group was treated with 2,4,6-triisopropylphenyllithium in the presence of a δ-lactone (Barbier-type reaction conditions) to afford a coupling product. The following deoxygenation gave the desired aryl-β-C-glycoside in good yield.

本文言語English
ページ(範囲)1007-1010
ページ数4
ジャーナルTetrahedron Letters
56
8
DOI
出版ステータスPublished - 2015 2 18

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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