Fundamental and clinical evaluation of ceftazidime in neonates and premature infants

Yoshitake Sato, Satoshi Iwata, Yutaka Kusumoto, Hiroyuki Shiro, Tadao Oikawa, Mitsuru Osano

研究成果: Article査読

抄録

Fundamental and clinical evaluation of ceftazidime (CAZ) were carried out in neonates and premature infants, and the results obtained are summerized below. 1. Serum concentrations of CAZ after administration of 20 mg/kg were satisfactorily high regardless of the route of administration; bolus intravenous injection or 1-hour intravenous drip infusion. Like other cephem antibiotics, half-lives tended to be shorter as day-ages of subject became higher. 2. Although there were some differences in urinary recovery rates between different dosage groups, they were generally high. 3. Clinical efficacy was either excellent or good in all 21 assessable cases. 4. In 23 cases examined for adverse effects, diarrhea was observed in 1 case, and elevation of GOT and GPT, in another case.

本文言語English
ページ(範囲)2084-2096
ページ数13
ジャーナルthe japanese journal of antibiotics
39
8
DOI
出版ステータスPublished - 1986 8月
外部発表はい

ASJC Scopus subject areas

  • 微生物学(医療)
  • 薬理学(医学)
  • 感染症

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