Fundamental and Clinical Studies on Aztreonam in Pediatrics

Keisuke Sunakawa, Nobuo Saito, Yugo Ishizuka, Satoshi Iwata, Yoshitake Sato, Hironobu Akita

研究成果: Article査読

1 被引用数 (Scopus)

抄録

Fundamental and clinical results of AZT in pediatrics were as follows. 1. Pharmacokinetics of AZT was studied for 1 case with resulting high serum concentration and a halflife of approximate 1 hour. 2. AZT was administered to 10 patients with bacterial infections with 100% clinical efficacy and 62.5% bacterial elimination. Side effect was 1 case of diarrhea. 3. There were no abnormal laboratory or coagulation test findings nor vitamin K deficiency, platelet hypofunction or effects on intestinal bacterial flora. AZT was considered to be high in safety. 4. The administration of 20 mg/kg AZT 3 times a day was considered to be an effective treatment for pediatric Gram-negative infections.

本文言語English
ページ(範囲)3230-3238
ページ数9
ジャーナルthe japanese journal of antibiotics
38
11
DOI
出版ステータスPublished - 1985

ASJC Scopus subject areas

  • 微生物学(医療)
  • 薬理学(医学)
  • 感染症

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