The pharmacokinetics and clinical studies were undertaken to evaluate the effect of intravenously administered cefluprenam (CFLP) on the surgical infections. 1. Peritoneal exudate was collected for 3 consecutive days through a Foleys balloon catheter inserted to the subphrenic space at the end of surgery. One g of CFLP was administered twice a day to 3 patients after gastrectomy for gastric cancer. CFLP levels in exudate at 1, 2 and 3 postoperative days were 8.0, 11. 1 and 11.1μg/ml in avarage respectively. The relative mean concentration of CFLP was 5.1μg/ml and belonged to the high value group among 30 β-lactams. 2. Concentration of CFLP in choledocus bile was studied on 1 patient of choledocolithiasis after cholecytectomy and T-tube drainage. Bile levels at 1, 2, 4, 6 and 8 hours after CFLP (1.0g) administration were 0.3, 0.3, 1.9, 4.0 and 4.7μg/ml respectively. 3. In the clinical study, 16 patients received intravenous CFLP (1 or 2g), bid for 4 ~ 16 days. Sixteen patients consisted of 2 cholangitis, 2 panperitonitis, 5 localized peritonitis, 3 postoperative wound infection, 1 burn wound infection, 1 ileopsoas abscess, 1 abdominal wall abscess and 1 periproctal abscess. The clinical effects were excellent in 2 cases, good in 12 cases, fair in 1 case and poor in 1 case ; overall clinical response rate in 16 cases was 87.5%. No adverse drug reaction was noted but slight abnormal laboratory finding in S-GPT was recognized in 1 case. These results suggested CFLP may be useful drug to surgical infections including intraperitoneal infections.
|ジャーナル||Japanese Journal of Chemotherapy|
|出版ステータス||Published - 1995|
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