Fungal β-Mannosyloxymannitol Glycolipids and Their Analogues: Synthesis and Mincle-Mediated Signaling Activity

Takanori Matsumaru, Kasumi Sakuratani, Saeko Yanaka, Koichi Kato, Sho Yamasaki, Yukari Fujimoto

研究成果: Article査読

抄録

Mincle, a C-type lectin receptor (CLR), senses certain lipid conjugates, leading to the activation of the innate immune system. The lipid conjugate ligands include glyco-, glycero-, and mannitol lipids. Recently, a fungal β-mannosyloxymannitol glycolipid demonstrating a novel architecture, “44-2,” was isolated from the fungus Malassezia and displayed potent Mincle-mediated signaling activity. For this study, we synthesized the diastereomeric pair of mannosyloxymannitol glycolipids and their analogues and analyzed the structure-activity relationships of Mincle-mediated signaling. The results suggest that the dimannosyl-fatty acid moiety in the mannosyloxymannitol glycolipid-type structure plays a major role in the molecular recognition of Mincle.

本文言語English
論文番号e202200109
ジャーナルEuropean Journal of Organic Chemistry
2022
20
DOI
出版ステータスPublished - 2022 5月 25

ASJC Scopus subject areas

  • 物理化学および理論化学
  • 有機化学

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