GABAergic interneuron migration and the evolution of the neocortex

Daisuke H. Tanaka, Kazunori Nakajima

研究成果: Review article査読

14 被引用数 (Scopus)

抄録

A neocortex is present in all mammals but is not present in other classes of vertebrates, and the neocortex is extremely elaborate in humans. Changes in excitatory projection neurons and their progenitors within the developing dorsal pallium in the most recent common ancestor of mammals are thought to have been involved in the evolution of the neocortex. Our recent findings suggest that changes in the migratory ability of inhibitory interneurons derived from outside the neocortex may also have been involved in the evolution of the neocortex. In this article we review the literature on the migratory profile of inhibitory interneurons in several different species and the literature on comparisons between the intrinsic migratory ability of interneurons derived from different species. Finally, we propose a hypothesis about the mammalian-specific evolution of the migratory ability of interneurons and its potential contribution to the establishment of a functional neocortex.

本文言語English
ページ(範囲)366-372
ページ数7
ジャーナルDevelopment Growth and Differentiation
54
3
DOI
出版ステータスPublished - 2012 4

ASJC Scopus subject areas

  • 発生生物学
  • 細胞生物学

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