Ganglioside-embedding small bicelles for probing membrane-landing processes of intrinsically disordered proteins

Takumi Yamaguchi, Tsuyoshi Uno, Yoshinori Uekusa, Maho Yagi-Utsumi, Koichi Kato

研究成果: Article査読

24 被引用数 (Scopus)

抄録

We successfully displayed a series of gangliosides on small bicelles with a uniform confined size, offering nanoscale standardized membrane mimics for spectroscopic characterization of weak encounter complexes formed between ganglioside clusters and amyloidogenic proteins. This enabled probing of initial membrane-landing processes of α-synuclein as a therapeutic target by NMR spectroscopy.

本文言語English
ページ(範囲)1235-1237
ページ数3
ジャーナルChemical Communications
49
12
DOI
出版ステータスPublished - 2013 1 1
外部発表はい

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

フィンガープリント 「Ganglioside-embedding small bicelles for probing membrane-landing processes of intrinsically disordered proteins」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル