TY - CHAP
T1 - Gastric non-helicobacter pylori helicobacter
T2 - Its significance in human gastric diseases
AU - Nakamura, Masahiko
AU - Øverby, Anders
AU - Murayama, Somay Y.
AU - Suzuki, Hidekazu
AU - Takahashi, Tetsufumi
AU - Takahashi, Shinichi
AU - Matsui, Hidenori
PY - 2016/1/1
Y1 - 2016/1/1
N2 - In the post-H. pylori eradication era, the clinical significance of gastric non-H. pylori helicobacters (NHPH; also referred to as H. heilmannii-like organisms and H. heilmannii sensu lato) is gradually increasing. This group of bacteria may inhabit the stomach of domestic and wild animals including cats, dogs, pigs, primates, rodents, cheetahs, and rabbits. NHPH are zoonotic microorganisms, meaning that they may transmit between animals and humans. They may be distinguished from H. pylori regarding their microbiology involving larger cells with more distinct spiral shape and bipolarity, localization in the stomach layer and regional distribution, urease activity and virulence factors, and relation to gastric diseases where gastric NHPH infection is often associated with milder gastritis than H. pylori but higher risk of gastric MALT lymphoma. At present, pure culture of NHPH species remains a challenge, but the full genome sequences of some of the species have been reported. Recent and ongoing prevalence studies indicate a higher clinical relevance of these bacteria than earlier impressions suggested. Current efforts in improving cultivation and detection methodology are contributing to an increased understanding of their microbiology, prevalence, and relevance to human diseases.
AB - In the post-H. pylori eradication era, the clinical significance of gastric non-H. pylori helicobacters (NHPH; also referred to as H. heilmannii-like organisms and H. heilmannii sensu lato) is gradually increasing. This group of bacteria may inhabit the stomach of domestic and wild animals including cats, dogs, pigs, primates, rodents, cheetahs, and rabbits. NHPH are zoonotic microorganisms, meaning that they may transmit between animals and humans. They may be distinguished from H. pylori regarding their microbiology involving larger cells with more distinct spiral shape and bipolarity, localization in the stomach layer and regional distribution, urease activity and virulence factors, and relation to gastric diseases where gastric NHPH infection is often associated with milder gastritis than H. pylori but higher risk of gastric MALT lymphoma. At present, pure culture of NHPH species remains a challenge, but the full genome sequences of some of the species have been reported. Recent and ongoing prevalence studies indicate a higher clinical relevance of these bacteria than earlier impressions suggested. Current efforts in improving cultivation and detection methodology are contributing to an increased understanding of their microbiology, prevalence, and relevance to human diseases.
KW - Helicobacter heilmannii
KW - Helicobacter suis
KW - Non-Helicobacter pylori helicobacter
KW - Zoonosis
UR - http://www.scopus.com/inward/record.url?scp=84978254156&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84978254156&partnerID=8YFLogxK
U2 - 10.1007/978-4-431-55705-0_8
DO - 10.1007/978-4-431-55705-0_8
M3 - Chapter
AN - SCOPUS:84978254156
SN - 9784431557043
SP - 131
EP - 140
BT - Helicobacter Pylori
PB - Springer Japan
ER -