Gastroduodenal Ulcers and ABO Blood Group: the Japan Nurses’ Health Study (JNHS)

Lobna Alkebsi, Yuki Ideno, Jung Su Lee, Shosuke Suzuki, Junko Nakajima-Shimada, Hiroshi Ohnishi, Yasunori Sato, Kunihiko Hayashi

研究成果: Article査読

4 被引用数 (Scopus)

抄録

Background: Although several studies have shown that blood type O is associated with increased risk of peptic ulcer, few studies have investigated these associations in Japan. We sought to investigate the association between the ABO blood group and risk of gastroduodenal ulcers (GDU) using combined analysis of both retrospective and prospective data from a large cohort study of Japanese women, the Japan Nurses’ Health Study (JNHS; n = 15,019). Methods: The impact of the ABO blood group on GDU risk was examined using Cox regression analysis to estimate hazard ratios (HRs) and 95% confidence intervals (CI), with adjustment for potential confounders. Results: Compared with women with non-O blood types (A, B, and AB), women with blood type O had a significantly increased risk of GDU from birth (multivariable-adjusted HR 1.18; 95% CI, 1.04–1.34). Moreover, the highest cumulative incidence of GDU was observed in women born pre-1956 with blood type O. In a subgroup analysis stratified by birth year (pre-1956 or post-1955), the multivariable-adjusted HR of women with blood type O was 1.22 (95% CI, 1.00–1.49) and 1.15 (95% CI, 0.98–1.35) in the pre-1956 and post-1955 groups, respectively. Conclusion: In this large, combined, ambispective cohort study of Japanese women, older women with blood type O had a higher risk of developing GDU than those with other blood types.

本文言語English
ページ(範囲)34-40
ページ数7
ジャーナルJournal of epidemiology
28
1
DOI
出版ステータスPublished - 2018
外部発表はい

ASJC Scopus subject areas

  • Epidemiology

フィンガープリント 「Gastroduodenal Ulcers and ABO Blood Group: the Japan Nurses’ Health Study (JNHS)」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル