Gatekeepers for Piwi-piRNA complexes to enter the nucleus

研究成果: Review article査読

22 被引用数 (Scopus)

抄録

RNA silencing pathways are now recognized to participate in essential cellular functions ranging from the regulation of mRNA turnover to the suppression of the activity of potentially deleterious transposable elements (TEs). Piwi-interacting RNAs (piRNAs) are germline-specific, small silencing RNAs that suppress TE activity and maintain genome integrity during germline development. In Drosophila ovarian somatic cells, piRNAs are processed from long single-stranded RNAs by a Dicer-independent pathway and are loaded onto Piwi in the cytoplasm. The Piwi-piRNA complexes are then transported into the nucleus to exert TE silencing. This mechanism involves gatekeepers for a functional Piwi-piRNA complex to be imported, which parallels with the Tetrahymena Twi1p-scan RNA pathway used to carry out the programmed DNA elimination.

本文言語English
ページ(範囲)484-490
ページ数7
ジャーナルCurrent Opinion in Genetics and Development
21
4
DOI
出版ステータスPublished - 2011 8月

ASJC Scopus subject areas

  • 遺伝学
  • 発生生物学

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