Gene transfer of human hepatocyte growth factor by the use of nanosecond pulsed laser-induced stress waves

Mitsuhiro Terakawa, Shunichi Sato, Daizoh Saitoh, Makoto Hasegawa, Hiroshi Ashida, Hideyuki Okano, Minoru Obara

研究成果: Conference contribution

抄録

We successfully delivered a therapeutic vector construct, which carries hepatocyte growth factor (HGF) gene, to rat skin in vivo. After HGF expression vector had been intradermally injected to rat skin, LISWs were generated by irradiating the laser target put on the rat skin with nanosecond pulses from the second harmonics (532 nm) of a Q-switched Nd:YAG laser. Concentration of HGF protein increased by a factor of four by the application of LISWs when compared with that of control samples without LISW application. We also investigated the effects of LISWs on the integrity of plasmid DNA.

本文言語English
ホスト出版物のタイトルHigh-Power Laser Ablation VI
DOI
出版ステータスPublished - 2006 8 23
イベントHigh-Power Laser Ablation VI - Taos, NM, United States
継続期間: 2006 5 72006 5 12

出版物シリーズ

名前Proceedings of SPIE - The International Society for Optical Engineering
6261 II
ISSN(印刷版)0277-786X

Other

OtherHigh-Power Laser Ablation VI
CountryUnited States
CityTaos, NM
Period06/5/706/5/12

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering

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