General treatment of mean residence time, clearance, and volume parameters in linear mammillary models with elimination from any compartment

Emi Nakashima, Leslie Z. Benet

研究成果: Article査読

54 被引用数 (Scopus)

抄録

A general treatment for mean residence time, clearance, and volume parameters in linear mammillary models which includes the possibility of first-order elimination from compartments other than the central compartment is presented. The interrelationship between noncompartmentally derived parameters and compartmentally derived pharmacokinetic microconstants is described. The concept of exit site dependent and exit site independent parameters is introduced in the development of these treatments. Explications of mean residence time in terms of elimination rate, amount eliminated, and amount in the body are presented together with demonstrations of their utility.

本文言語English
ページ(範囲)475-492
ページ数18
ジャーナルJournal of Pharmacokinetics and Biopharmaceutics
16
5
DOI
出版ステータスPublished - 1988 10

ASJC Scopus subject areas

  • 薬理学、毒性学および薬学(全般)
  • 薬理学(医学)

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