General treatment of mean residence time, clearance, and volume parameters in linear mammillary models with elimination from any compartment

Emi Nakashima, Leslie Z. Benet

研究成果: Article

53 引用 (Scopus)

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A general treatment for mean residence time, clearance, and volume parameters in linear mammillary models which includes the possibility of first-order elimination from compartments other than the central compartment is presented. The interrelationship between noncompartmentally derived parameters and compartmentally derived pharmacokinetic microconstants is described. The concept of exit site dependent and exit site independent parameters is introduced in the development of these treatments. Explications of mean residence time in terms of elimination rate, amount eliminated, and amount in the body are presented together with demonstrations of their utility.

元の言語English
ページ(範囲)475-492
ページ数18
ジャーナルJournal of Pharmacokinetics and Biopharmaceutics
16
発行部数5
DOI
出版物ステータスPublished - 1988 10 1

ASJC Scopus subject areas

  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Pharmacology (medical)

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