Generation of mouse ES cell lines engineered for the forced induction of transcription factors

Lina S. Correa-Cerro, Yulan Piao, Alexei A. Sharov, Akira Nishiyama, Jean S. Cadet, Hong Yu, Lioudmila V. Sharova, Li Xin, Hien G. Hoang, Marshall Thomas, Yong Qian, Dawood B. Dudekula, Emily Meyers, Bernard Y. Binder, Gregory Mowrer, Uwem Bassey, Dan L. Longo, David Schlessinger, Minoru S.H. Ko

研究成果: Article

31 引用 (Scopus)

抜粋

Here we report the generation and characterization of 84 mouse ES cell lines with doxycycline-controllable transcription factors (TFs) which, together with the previous 53 lines, cover 7-10% of all TFs encoded in the mouse genome. Global gene expression profiles of all 137 lines after the induction of TFs for 48 hrs can associate each TF with the direction of ES cell differentiation, regulatory pathways, and mouse phenotypes. These cell lines and microarray data provide building blocks for a variety of future biomedical research applications as a community resource.

元の言語English
記事番号167
ジャーナルScientific reports
1
DOI
出版物ステータスPublished - 2011

ASJC Scopus subject areas

  • General

フィンガープリント Generation of mouse ES cell lines engineered for the forced induction of transcription factors' の研究トピックを掘り下げます。これらはともに一意のフィンガープリントを構成します。

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    Correa-Cerro, L. S., Piao, Y., Sharov, A. A., Nishiyama, A., Cadet, J. S., Yu, H., Sharova, L. V., Xin, L., Hoang, H. G., Thomas, M., Qian, Y., Dudekula, D. B., Meyers, E., Binder, B. Y., Mowrer, G., Bassey, U., Longo, D. L., Schlessinger, D., & Ko, M. S. H. (2011). Generation of mouse ES cell lines engineered for the forced induction of transcription factors. Scientific reports, 1, [167]. https://doi.org/10.1038/srep00167