Genes highly expressed in the early phase of murine graft-versus-host reaction

Masatoshi Wakui, Daisuke Sakurai, Naoyuki Tsuchiya, Katsushi Tokunaga, Masatoshi Wakui, Yasuo Ikeda, Akihiro Yamaguchi, Kouetsu Ogasawara, Taeko Yokochi

研究成果: Article査読

5 被引用数 (Scopus)

抄録

Graft-versus-host reaction (GVHR) is a complex process initiated upon allorecognition. For detection of early molecular events in GVHR, we first assessed time courses with respect to symptoms and serum interferon (IFN)-γ levels and then used the differential display method to compare gene transcript patterns during the early phase between acute lethal GVHR mice and syngeneic controls. In the GVHR mice, high expression levels of seven genes encoding the following molecules were detected: TGTP/Mg21 (an IFN-γ-related signaling molecule), vitronectin, Nedd5 (a mammalian septin), manganese superoxide dismutase, activin βC subunit, PRCC (a papillary renal cell carcinoma-associated molecule), and an uncharacterized gene corresponding to a mouse expressed sequence tag (EST). The expression levels of most genes peaked before the symptomatological onset and the peak of IFN-γ levels. Thus, gene expression monitoring may characterize the inductive process of GVHR and aid in the development of gene-based diagnostics and therapies.

本文言語English
ページ(範囲)200-206
ページ数7
ジャーナルBiochemical and Biophysical Research Communications
282
1
DOI
出版ステータスPublished - 2001
外部発表はい

ASJC Scopus subject areas

  • 生物理学
  • 生化学
  • 分子生物学
  • 細胞生物学

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