TY - JOUR
T1 - Genetic linkage of the sarco(endo)plasmic reticulum Ca2+-dependent ATPase II gene to intracellular Ca2+ concentration in the spontaneously hypertensive rat
AU - Ohno, Yoichi
AU - Matsuo, Koichi
AU - Suzuki, Hiromichi
AU - Tanase, Hisao
AU - Serikawa, Tadao
AU - Takano, Toshiya
AU - Saruta, Takao
N1 - Funding Information:
This work was supported by a research grant for cardiovascular diseases (3C-5) from the Ministry of Health and Welfare and the National Dairy Promotion and Research Association and by Keio Gijuku Academic Development Funds.
PY - 1996/10/23
Y1 - 1996/10/23
N2 - A cosegregation analysis of sarco(endo)plasmic reticulum Ca2+-dependent ATPase (SERCA) II genotype, systolic blood pressure and platelet intracellular Ca2+ concentration was performed to dissect polygenic hypertensive traits in spontaneously hypertensive rats. Backcross analysis between spontaneously hypertensive hypertensive rats and normotensive Donryu rats demonstrated the existence of an inferred single major gene locus (ht). Thrombin-stimulated intraplatelet Ca2+ concentration was significantly higher in the SERCA II homozygotes than in the heterozygotes. The SERCA II genotype did not cosegregate with the blood pressure level. The SERCA II gene was assigned to rat chromosome 12. These results suggest that the SERCA II gene on rat chromosome 12 contributes to increased thrombin-stimulated intraplatelet Ca2+ concentration and that the SERCA II gene is not identical to ht.
AB - A cosegregation analysis of sarco(endo)plasmic reticulum Ca2+-dependent ATPase (SERCA) II genotype, systolic blood pressure and platelet intracellular Ca2+ concentration was performed to dissect polygenic hypertensive traits in spontaneously hypertensive rats. Backcross analysis between spontaneously hypertensive hypertensive rats and normotensive Donryu rats demonstrated the existence of an inferred single major gene locus (ht). Thrombin-stimulated intraplatelet Ca2+ concentration was significantly higher in the SERCA II homozygotes than in the heterozygotes. The SERCA II genotype did not cosegregate with the blood pressure level. The SERCA II gene was assigned to rat chromosome 12. These results suggest that the SERCA II gene on rat chromosome 12 contributes to increased thrombin-stimulated intraplatelet Ca2+ concentration and that the SERCA II gene is not identical to ht.
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U2 - 10.1006/bbrc.1996.1586
DO - 10.1006/bbrc.1996.1586
M3 - Article
C2 - 8886011
AN - SCOPUS:0030599443
VL - 227
SP - 789
EP - 793
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
SN - 0006-291X
IS - 3
ER -