@article{606142ae94a349cd8abaaa97a9a51fe5,
title = "Genome-wide association study identifies three novel loci for type 2 diabetes",
abstract = "Although over 60loci for type 2 diabetes (T2D) havebeenidentified, there still remains a large geneticcomponent to be clarified. To explore unidentified loci for T2D, we performed a genome-wide association study (GWAS) of 6 209 637 single-nucleotide polymorphisms (SNPs), which were directly genotyped or imputed using East Asian references from the 1000 Genomes Project (June 2011 release) in 5976 Japanese patients with T2D and 20 829 nondiabetic individuals. Nineteen unreported loci were selected and taken forward to follow-up analyses. Combined discovery and follow-up analyses (30 392 cases and 34 814 controls) identified three new loci with genome-wide significance, which were MIR129-LEP [rs791595; risk allele 5 A; risk allele frequency (RAF) 5 0.080; P 5 2.55 × 10-13; odds ratio (OR) 5 1.17], GPSM1 [rs11787792; risk allele 5 A; RAF 5 0.874; P 5 1.74 × 10-10; OR 5 1.15] and SLC16A13 (rs312457; risk allele 5 G; RAF 5 0.078; P 5 7.69 × 10-13; OR 5 1.20). This study demonstrates that GWASs based on the imputation of genotypes using modern reference haplotypes such as that from the 1000 Genomes Project data can assist in identification of new loci for common diseases.",
author = "Kazuo Hara and Hayato Fujita and Johnson, {Todd A.} and Toshimasa Yamauchi and Kazuki Yasuda and Momoko Horikoshi and Chen Peng and Cheng Hu and Ma, {Ronald C.W.} and Minako Imamura and Minoru Iwata and Tatsuhiko Tsunoda and Takashi Morizono and Nobuhiro Shojima and So, {Wing Yee} and Leung, {Ting Fan} and Patrick Kwan and Rong Zhang and Jie Wang and Weihui Yu and Hiroshi Maegawa and Hiroshi Hirose and Kohei Kaku and Chikako Ito and Hirotaka Watada and Yasushi Tanaka and Kazuyuki Tobe and Atsunori Kashiwagi and Ryuzo Kawamori and Weiping Jia and Chan, {Juliana C.N.} and Teo, {Yik Ying} and Shyong, {Tai E.} and Naoyuki Kamatani and Michiaki Kubo and Shiro Maeda and Takashi Kadowaki",
note = "Funding Information: This work was supported by a grant from the Leading Project of Ministry of Education, Culture, Sports, Science and Technology, Japan. S.J.T.U.: We thank all medical staff of the Shanghai Clinical Center for Diabetes. This work was supported by grants from the National 973 Program (2011CB504001), 863 Program (2006AA02A409), National Science Foundation of China (30800617, 81170735), Excellent Young Medical Expert of Shanghai (XYQ2011041) and the major program of the Shanghai Municipality for Basic Research (08dj1400601), China. SP2: The Singapore BioBank and the Genome Institute of Singapore, Agency for Science, Technology, and Research provided services for tissue archival and genotyping, respectively. This work was supported by grants from the Biomedical Research Council of Singapore (BMRC 05/1/36/19/413 and 03/1/27/18/ 216) and the National Medical Research Council of Singapore (NMRC/1174/2008).C.U.H.K.: We thank all medical and nursing staff of the Prince of Wales Hospital Diabetes Mellitus Education Centre for their commitment and professionalism. We would like to thank the Genome Institution at Quebec for help with replication genotyping, and the Chinese University of Hong Kong Information Technology Services Centre for their support with computing resources. This work was supported by the Hong Kong Foundation for Research and Development in Diabetes established under the auspices of the Chinese University of Hong Kong, the Hong Kong Government Research Grant Committee Central Allocation Scheme (CUHK 1/04C), Research Grants Council Earmarked Research Grant (CUHK4727/0M), the Innovation and Technology Fund (ITS/ 088/08 and ITS/487/09FP), a Chinese University Direct Grant, the Research Fund of the Department of Medicine and Therapeutics and the Diabetes and Endocrine Research Fund of the Chinese University of Hong Kong. The summary results of DIAGRAMv3 study were downloaded via the website at http:// diagram-consortium.org/index.html.",
year = "2014",
month = jan,
doi = "10.1093/hmg/ddt399",
language = "English",
volume = "23",
pages = "239--246",
journal = "Human Molecular Genetics",
issn = "0964-6906",
publisher = "Oxford University Press",
number = "1",
}
