@article{0704fef326e349c4914bf08f4945bbcc,
title = "Genome-wide distribution of linker histone H1.0 is independent of MeCP2",
abstract = "Previous studies suggested that MeCP2 competes with linker histone H1, but this hypothesis has never been tested in vivo. Here, we performed chromatin immunoprecipitation followed by sequencing (ChIP-seq) of Flag-tagged-H1.0 in mouse forebrain excitatory neurons. Unexpectedly, Flag-H1.0 and MeCP2 occupied similar genomic regions and the Flag-H1.0 binding was not changed upon MeCP2 depletion. Furthermore, mild overexpression of H1.0 did not alter MeCP2 binding, suggesting that the functional binding of MeCP2 and H1.0 are largely independent.",
author = "Aya Ito-Ishida and Yamalanchili, {Hari Krishna} and Yingyao Shao and Baker, {Steven A.} and Heckman, {Laura D.} and Lavery, {Laura A.} and Kim, {Ji Yoen} and Lombardi, {Laura M.} and Yaling Sun and Zhandong Liu and Zoghbi, {Huda Y.}",
note = "Funding Information: This research was supported by NIH/NINDS 5R01NS057819 (H.Y.Z.), the Japan Society for the Promotion of Science (A.I.-I.), Genetically Engineered Mouse Core and Genomic and RNA Profiling Core at BCM, Neurovisualization Core at the BCM Intellectual and Developmental Disabilities Research Center (NIH/1U54HD083092), and NSF DMS#1263932 and CPRIT RP170387 (Z.L.). H.Y.Z. is an investigator with the Howard Hughes Medical Institute. Publisher Copyright: {\textcopyright} 2018 The Author(s).",
year = "2018",
month = jun,
day = "1",
doi = "10.1038/s41593-018-0155-8",
language = "English",
volume = "21",
pages = "794--798",
journal = "Nature Neuroscience",
issn = "1097-6256",
publisher = "Nature Publishing Group",
number = "6",
}