Genotype frequency of plasminogen activator inhibitor-1 (PAI-1) 4G/5G polymorphism in healthy Japanese males and its relation to PAI-1 levels

Yumiko Matsubara, Mitsuru Murata, Ikuko Isshiki, Reiko Watanabe, Takeru Zama, Gentaro Watanabe, Kiyoaki Watanabe, Yasuo Ikeda

研究成果: Article

33 引用 (Scopus)

抄録

Plasminogen activator inhibitor-1 (PAI-1) plays an inhibitory role in the fibrinolytic enzyme system and is associated with thrombotic diseases. The gene for PAI-1 has an insertion/deletion polymorphism at the promoter region, the 4G/5G polymorphism, which is related to differences in transcription activity in vitro. Association of the 4G/5G polymorphism with plasma PAI-1 levels, however, has not been uniformly reported. We evaluated the relationship between the 4G/5G polymorphism and plasma PAI-1 antigen levels in 104 Japanese males not taking lipid-lowering drugs and without non-insulin-dependent (type 2) diabetes mellitus or coronary artery disease. The genotype frequency was 37.5%, 50.0%, and 12.5% for 4G/4G,4G/5G, and 5G/5G genotypes, respectively, which differs from that reported for healthy Caucasian males (P < 0.01), with the 4G allele more frequently found in the Japanese population. No association was found between the 4G/5G polymorphism and plasma PAI-1 antigen levels. Multiple regression analysis revealed a significant (P < 0.01) contribution of triglyceride (TG) levels to variations in plasma PAI-1 antigen levels. The correlation between TG levels and plasma PAI-1 antigen levels was not 4G/5G genotype-specific. These findings suggest that PAI-1 4G/5G polymorphism is not associated with plasma PAI-1 antigen levels among healthy Japanese males and that TG levels correlate to plasma PAI-1 antigen levels in all PAI-1 4G/5G genotypes.

元の言語English
ページ(範囲)43-47
ページ数5
ジャーナルInternational Journal of Hematology
69
発行部数1
出版物ステータスPublished - 1999

Fingerprint

Plasminogen Activator Inhibitor 1
Genotype
Antigens
Triglycerides
Type 2 Diabetes Mellitus
Genetic Promoter Regions
Coronary Artery Disease
Alleles
Regression Analysis
Lipids

ASJC Scopus subject areas

  • Hematology

これを引用

Genotype frequency of plasminogen activator inhibitor-1 (PAI-1) 4G/5G polymorphism in healthy Japanese males and its relation to PAI-1 levels. / Matsubara, Yumiko; Murata, Mitsuru; Isshiki, Ikuko; Watanabe, Reiko; Zama, Takeru; Watanabe, Gentaro; Watanabe, Kiyoaki; Ikeda, Yasuo.

:: International Journal of Hematology, 巻 69, 番号 1, 1999, p. 43-47.

研究成果: Article

Matsubara, Y, Murata, M, Isshiki, I, Watanabe, R, Zama, T, Watanabe, G, Watanabe, K & Ikeda, Y 1999, 'Genotype frequency of plasminogen activator inhibitor-1 (PAI-1) 4G/5G polymorphism in healthy Japanese males and its relation to PAI-1 levels', International Journal of Hematology, 巻. 69, 番号 1, pp. 43-47.
Matsubara, Yumiko ; Murata, Mitsuru ; Isshiki, Ikuko ; Watanabe, Reiko ; Zama, Takeru ; Watanabe, Gentaro ; Watanabe, Kiyoaki ; Ikeda, Yasuo. / Genotype frequency of plasminogen activator inhibitor-1 (PAI-1) 4G/5G polymorphism in healthy Japanese males and its relation to PAI-1 levels. :: International Journal of Hematology. 1999 ; 巻 69, 番号 1. pp. 43-47.
@article{d522a4e4c5844ad6acf25c597da85c8a,
title = "Genotype frequency of plasminogen activator inhibitor-1 (PAI-1) 4G/5G polymorphism in healthy Japanese males and its relation to PAI-1 levels",
abstract = "Plasminogen activator inhibitor-1 (PAI-1) plays an inhibitory role in the fibrinolytic enzyme system and is associated with thrombotic diseases. The gene for PAI-1 has an insertion/deletion polymorphism at the promoter region, the 4G/5G polymorphism, which is related to differences in transcription activity in vitro. Association of the 4G/5G polymorphism with plasma PAI-1 levels, however, has not been uniformly reported. We evaluated the relationship between the 4G/5G polymorphism and plasma PAI-1 antigen levels in 104 Japanese males not taking lipid-lowering drugs and without non-insulin-dependent (type 2) diabetes mellitus or coronary artery disease. The genotype frequency was 37.5{\%}, 50.0{\%}, and 12.5{\%} for 4G/4G,4G/5G, and 5G/5G genotypes, respectively, which differs from that reported for healthy Caucasian males (P < 0.01), with the 4G allele more frequently found in the Japanese population. No association was found between the 4G/5G polymorphism and plasma PAI-1 antigen levels. Multiple regression analysis revealed a significant (P < 0.01) contribution of triglyceride (TG) levels to variations in plasma PAI-1 antigen levels. The correlation between TG levels and plasma PAI-1 antigen levels was not 4G/5G genotype-specific. These findings suggest that PAI-1 4G/5G polymorphism is not associated with plasma PAI-1 antigen levels among healthy Japanese males and that TG levels correlate to plasma PAI-1 antigen levels in all PAI-1 4G/5G genotypes.",
keywords = "4G/5G, Japanese, Plasminogen activator inhibitor-1, Polymorphism, Triglyceride",
author = "Yumiko Matsubara and Mitsuru Murata and Ikuko Isshiki and Reiko Watanabe and Takeru Zama and Gentaro Watanabe and Kiyoaki Watanabe and Yasuo Ikeda",
year = "1999",
language = "English",
volume = "69",
pages = "43--47",
journal = "International Journal of Hematology",
issn = "0925-5710",
publisher = "Springer Japan",
number = "1",

}

TY - JOUR

T1 - Genotype frequency of plasminogen activator inhibitor-1 (PAI-1) 4G/5G polymorphism in healthy Japanese males and its relation to PAI-1 levels

AU - Matsubara, Yumiko

AU - Murata, Mitsuru

AU - Isshiki, Ikuko

AU - Watanabe, Reiko

AU - Zama, Takeru

AU - Watanabe, Gentaro

AU - Watanabe, Kiyoaki

AU - Ikeda, Yasuo

PY - 1999

Y1 - 1999

N2 - Plasminogen activator inhibitor-1 (PAI-1) plays an inhibitory role in the fibrinolytic enzyme system and is associated with thrombotic diseases. The gene for PAI-1 has an insertion/deletion polymorphism at the promoter region, the 4G/5G polymorphism, which is related to differences in transcription activity in vitro. Association of the 4G/5G polymorphism with plasma PAI-1 levels, however, has not been uniformly reported. We evaluated the relationship between the 4G/5G polymorphism and plasma PAI-1 antigen levels in 104 Japanese males not taking lipid-lowering drugs and without non-insulin-dependent (type 2) diabetes mellitus or coronary artery disease. The genotype frequency was 37.5%, 50.0%, and 12.5% for 4G/4G,4G/5G, and 5G/5G genotypes, respectively, which differs from that reported for healthy Caucasian males (P < 0.01), with the 4G allele more frequently found in the Japanese population. No association was found between the 4G/5G polymorphism and plasma PAI-1 antigen levels. Multiple regression analysis revealed a significant (P < 0.01) contribution of triglyceride (TG) levels to variations in plasma PAI-1 antigen levels. The correlation between TG levels and plasma PAI-1 antigen levels was not 4G/5G genotype-specific. These findings suggest that PAI-1 4G/5G polymorphism is not associated with plasma PAI-1 antigen levels among healthy Japanese males and that TG levels correlate to plasma PAI-1 antigen levels in all PAI-1 4G/5G genotypes.

AB - Plasminogen activator inhibitor-1 (PAI-1) plays an inhibitory role in the fibrinolytic enzyme system and is associated with thrombotic diseases. The gene for PAI-1 has an insertion/deletion polymorphism at the promoter region, the 4G/5G polymorphism, which is related to differences in transcription activity in vitro. Association of the 4G/5G polymorphism with plasma PAI-1 levels, however, has not been uniformly reported. We evaluated the relationship between the 4G/5G polymorphism and plasma PAI-1 antigen levels in 104 Japanese males not taking lipid-lowering drugs and without non-insulin-dependent (type 2) diabetes mellitus or coronary artery disease. The genotype frequency was 37.5%, 50.0%, and 12.5% for 4G/4G,4G/5G, and 5G/5G genotypes, respectively, which differs from that reported for healthy Caucasian males (P < 0.01), with the 4G allele more frequently found in the Japanese population. No association was found between the 4G/5G polymorphism and plasma PAI-1 antigen levels. Multiple regression analysis revealed a significant (P < 0.01) contribution of triglyceride (TG) levels to variations in plasma PAI-1 antigen levels. The correlation between TG levels and plasma PAI-1 antigen levels was not 4G/5G genotype-specific. These findings suggest that PAI-1 4G/5G polymorphism is not associated with plasma PAI-1 antigen levels among healthy Japanese males and that TG levels correlate to plasma PAI-1 antigen levels in all PAI-1 4G/5G genotypes.

KW - 4G/5G

KW - Japanese

KW - Plasminogen activator inhibitor-1

KW - Polymorphism

KW - Triglyceride

UR - http://www.scopus.com/inward/record.url?scp=0032599948&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032599948&partnerID=8YFLogxK

M3 - Article

C2 - 10641442

AN - SCOPUS:0032599948

VL - 69

SP - 43

EP - 47

JO - International Journal of Hematology

JF - International Journal of Hematology

SN - 0925-5710

IS - 1

ER -