Geranylgeranylacetone protects cultured guinea pig gastric mucosal cells from indomethacin

W. Tomisato, N. Takahashi, C. Komoto, K. Rokutan, T. Tsuchiya, T. Mizushima

研究成果: Article

42 引用 (Scopus)

抜粋

One of the major side effects of nonsteroidal antiinflammatory drugs, such as indomethacin, is gastropathy. The purpose of this study was to search for a therapeutic drug to prevent this side effect in vitro. We found that geranylgeranylacetone, a unique antiulcer drug with a heat-shock protein-inducing ability, protected cultured guinea pig gastric mucosal cells from cell damage caused by indomethacin. This cytoprotective effect of geranylgeranylacetone required concentrations of more than 10-6 M and incubation periods of longer than 2 hr. Pretreatment of cells with an inhibitor of protein synthesis completely abolished the cytoprotective effect of geranylgeranylacetone, suggesting that some proteins induced by the drug are responsible for the cytoprotection. Since pretreatment of cells with low concentrations of ethanol, which also induced the heat-shock proteins, made cells resistant to indomethacin, heat-shock proteins are candidates for the proteins that are involved in the cytoprotective effect of geranylgeranylacetone against indomethacin.

元の言語English
ページ(範囲)1674-1679
ページ数6
ジャーナルDigestive Diseases and Sciences
45
発行部数8
DOI
出版物ステータスPublished - 2000
外部発表Yes

    フィンガープリント

ASJC Scopus subject areas

  • Gastroenterology

これを引用

Tomisato, W., Takahashi, N., Komoto, C., Rokutan, K., Tsuchiya, T., & Mizushima, T. (2000). Geranylgeranylacetone protects cultured guinea pig gastric mucosal cells from indomethacin. Digestive Diseases and Sciences, 45(8), 1674-1679. https://doi.org/10.1023/A:1005597902470