Geranylgeranylacetone suppresses spontaneous apoptotic DNA fragmentation in cultured guinea pig gastric pit cells

Shinji Tsutsumi, Kazuhito Rokutan, Tomofusa Tsuchiya, Tohru Mizushima

研究成果: Article査読

12 被引用数 (Scopus)

抄録

We recently found that guinea pig gastric pit cells in culture undergo spontaneous and rapid apoptotic DNA fragmentation, which may represent the rapid death of gastric pit cells in vivo. In this study, we observed that pretreatment of cells with geranylgeranylacetone, an antiulcer drug with heat-shock proteininducing activity, suppressed the spontaneous apoptotic DNA fragmentation in a dose-dependent manner. Pretreatment of cells with low concentrations of ethanol or heat-shock also prevented the spontaneous apoptotic DNA fragmentation. These observations indicate that the suppression of the apoptotic DNA fragmentation by geranylgeranylacetone involve the induction of heat-shock proteins.

本文言語English
ページ(範囲)886-887
ページ数2
ジャーナルBiological and Pharmaceutical Bulletin
22
8
DOI
出版ステータスPublished - 1999 8月

ASJC Scopus subject areas

  • 薬理学
  • 薬科学

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