抜粋
A new compound, gerfelin, was isolated from a culture broth of Beauveria felina QN22047. It was purified by column chromatography on silica gel and by HPLC. Gerfelin has the molecular formula C15H14O6. It inhibited synthesis of geranylgeranyl diphosphate, which was mediated by recombinant human geranylgeranyl diphosphate synthase (hGGPP synthase) in vitro. The inhibitory pattern of gerfelin was noncompetitive against isopentenyl diphosphate, and uncompetitive against farnesyl diphosphate.
| 元の言語 | English |
|---|---|
| ページ（範囲） | 617-621 |
| ページ数 | 5 |
| ジャーナル | Journal of Antibiotics |
| 巻 | 56 |
| 発行部数 | 7 |
| DOI | |
| 出版物ステータス | Published - 2003 8 1 |
ASJC Scopus subject areas
- Pharmacology
- Drug Discovery
フィンガープリント Gerfelin, a novel inhibitor of geranylgeranyl diphosphate synthase from Beauveria felina QN22047. I. Taxonomy, fermentation, isolation, and biological activities' の研究トピックを掘り下げます。これらはともに一意のフィンガープリントを構成します。
これを引用
Zenitani, S., Tashiro, S., Shindo, K., Nagai, K., Suzuki, K., & Imoto, M. (2003). Gerfelin, a novel inhibitor of geranylgeranyl diphosphate synthase from Beauveria felina QN22047. I. Taxonomy, fermentation, isolation, and biological activities. Journal of Antibiotics, 56(7), 617-621. https://doi.org/10.7164/antibiotics.56.617