Gerfelin, a novel inhibitor of geranylgeranyl diphosphate synthase from Beauveria felina QN22047. I. Taxonomy, fermentation, isolation, and biological activities

Satoko Zenitani, Satoshi Tashiro, Kazutoshi Shindo, Koji Nagai, Kenichi Suzuki, Masaya Imoto

研究成果: Article

29 引用 (Scopus)

抜粋

A new compound, gerfelin, was isolated from a culture broth of Beauveria felina QN22047. It was purified by column chromatography on silica gel and by HPLC. Gerfelin has the molecular formula C15H14O6. It inhibited synthesis of geranylgeranyl diphosphate, which was mediated by recombinant human geranylgeranyl diphosphate synthase (hGGPP synthase) in vitro. The inhibitory pattern of gerfelin was noncompetitive against isopentenyl diphosphate, and uncompetitive against farnesyl diphosphate.

元の言語English
ページ(範囲)617-621
ページ数5
ジャーナルJournal of Antibiotics
56
発行部数7
DOI
出版物ステータスPublished - 2003 8 1

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

フィンガープリント Gerfelin, a novel inhibitor of geranylgeranyl diphosphate synthase from Beauveria felina QN22047. I. Taxonomy, fermentation, isolation, and biological activities' の研究トピックを掘り下げます。これらはともに一意のフィンガープリントを構成します。

  • これを引用