Gerfelin, a novel inhibitor of geranylgeranyl diphosphate synthase from Beauveria felina QN22047. I. Taxonomy, fermentation, isolation, and biological activities

Satoko Zenitani; Satoshi Tashiro; Kazutoshi Shindo; Koji Nagai; Kenichi Suzuki; Masaya Imoto

doi:10.7164/antibiotics.56.617

Gerfelin, a novel inhibitor of geranylgeranyl diphosphate synthase from Beauveria felina QN22047. I. Taxonomy, fermentation, isolation, and biological activities

Satoko Zenitani, Satoshi Tashiro, Kazutoshi Shindo, Koji Nagai, Kenichi Suzuki, Masaya Imoto

生命情報学科

研究成果: Article › 査読

32 被引用数 (Scopus)

抄録

A new compound, gerfelin, was isolated from a culture broth of Beauveria felina QN22047. It was purified by column chromatography on silica gel and by HPLC. Gerfelin has the molecular formula C₁₅H₁₄O₆. It inhibited synthesis of geranylgeranyl diphosphate, which was mediated by recombinant human geranylgeranyl diphosphate synthase (hGGPP synthase) in vitro. The inhibitory pattern of gerfelin was noncompetitive against isopentenyl diphosphate, and uncompetitive against farnesyl diphosphate.

本文言語	English
ページ（範囲）	617-621
ページ数	5
ジャーナル	Journal of Antibiotics
巻	56
号	7
DOI	https://doi.org/10.7164/antibiotics.56.617
出版ステータス	Published - 2003 8月 1

ASJC Scopus subject areas

薬理学
創薬

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10.7164/antibiotics.56.617

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引用スタイル

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abstract = "A new compound, gerfelin, was isolated from a culture broth of Beauveria felina QN22047. It was purified by column chromatography on silica gel and by HPLC. Gerfelin has the molecular formula C15H14O6. It inhibited synthesis of geranylgeranyl diphosphate, which was mediated by recombinant human geranylgeranyl diphosphate synthase (hGGPP synthase) in vitro. The inhibitory pattern of gerfelin was noncompetitive against isopentenyl diphosphate, and uncompetitive against farnesyl diphosphate.",

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AU - Nagai, Koji

AU - Suzuki, Kenichi

AU - Imoto, Masaya

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