Gerfelin, a novel inhibitor of geranylgeranyl diphosphate synthase from Beauveria felina QN22047. I. Taxonomy, fermentation, isolation, and biological activities

Satoko Zenitani, Satoshi Tashiro, Kazutoshi Shindo, Koji Nagai, Kenichi Suzuki, Masaya Imoto

研究成果: Article

29 引用 (Scopus)

抄録

A new compound, gerfelin, was isolated from a culture broth of Beauveria felina QN22047. It was purified by column chromatography on silica gel and by HPLC. Gerfelin has the molecular formula C15H14O6. It inhibited synthesis of geranylgeranyl diphosphate, which was mediated by recombinant human geranylgeranyl diphosphate synthase (hGGPP synthase) in vitro. The inhibitory pattern of gerfelin was noncompetitive against isopentenyl diphosphate, and uncompetitive against farnesyl diphosphate.

元の言語English
ページ(範囲)617-621
ページ数5
ジャーナルJournal of Antibiotics
56
発行部数7
出版物ステータスPublished - 2003 8 1

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Beauveria
Farnesyltranstransferase
Fermentation
Silica Gel
Chromatography
High Pressure Liquid Chromatography
4-carboxy-5,5'-dihydroxy-3,3'-dimethyl-diphenylether

ASJC Scopus subject areas

  • Pharmacology
  • Molecular Medicine

これを引用

Gerfelin, a novel inhibitor of geranylgeranyl diphosphate synthase from Beauveria felina QN22047. I. Taxonomy, fermentation, isolation, and biological activities. / Zenitani, Satoko; Tashiro, Satoshi; Shindo, Kazutoshi; Nagai, Koji; Suzuki, Kenichi; Imoto, Masaya.

:: Journal of Antibiotics, 巻 56, 番号 7, 01.08.2003, p. 617-621.

研究成果: Article

Zenitani, Satoko ; Tashiro, Satoshi ; Shindo, Kazutoshi ; Nagai, Koji ; Suzuki, Kenichi ; Imoto, Masaya. / Gerfelin, a novel inhibitor of geranylgeranyl diphosphate synthase from Beauveria felina QN22047. I. Taxonomy, fermentation, isolation, and biological activities. :: Journal of Antibiotics. 2003 ; 巻 56, 番号 7. pp. 617-621.
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AU - Suzuki, Kenichi

AU - Imoto, Masaya

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