抄録
A new compound, gerfelin, was isolated from a culture broth of Beauveria felina QN22047. It was purified by column chromatography on silica gel and by HPLC. Gerfelin has the molecular formula C15H14O6. It inhibited synthesis of geranylgeranyl diphosphate, which was mediated by recombinant human geranylgeranyl diphosphate synthase (hGGPP synthase) in vitro. The inhibitory pattern of gerfelin was noncompetitive against isopentenyl diphosphate, and uncompetitive against farnesyl diphosphate.
| 元の言語 | English |
|---|---|
| ページ（範囲） | 617-621 |
| ページ数 | 5 |
| ジャーナル | Journal of Antibiotics |
| 巻 | 56 |
| 発行部数 | 7 |
| 出版物ステータス | Published - 2003 8 1 |
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ASJC Scopus subject areas
- Pharmacology
- Molecular Medicine
これを引用
Gerfelin, a novel inhibitor of geranylgeranyl diphosphate synthase from Beauveria felina QN22047. I. Taxonomy, fermentation, isolation, and biological activities. / Zenitani, Satoko; Tashiro, Satoshi; Shindo, Kazutoshi; Nagai, Koji; Suzuki, Kenichi; Imoto, Masaya.
：: Journal of Antibiotics, 巻 56, 番号 7, 01.08.2003, p. 617-621.研究成果: Article
}
TY - JOUR
T1 - Gerfelin, a novel inhibitor of geranylgeranyl diphosphate synthase from Beauveria felina QN22047. I. Taxonomy, fermentation, isolation, and biological activities
AU - Zenitani, Satoko
AU - Tashiro, Satoshi
AU - Shindo, Kazutoshi
AU - Nagai, Koji
AU - Suzuki, Kenichi
AU - Imoto, Masaya
PY - 2003/8/1
Y1 - 2003/8/1
N2 - A new compound, gerfelin, was isolated from a culture broth of Beauveria felina QN22047. It was purified by column chromatography on silica gel and by HPLC. Gerfelin has the molecular formula C15H14O6. It inhibited synthesis of geranylgeranyl diphosphate, which was mediated by recombinant human geranylgeranyl diphosphate synthase (hGGPP synthase) in vitro. The inhibitory pattern of gerfelin was noncompetitive against isopentenyl diphosphate, and uncompetitive against farnesyl diphosphate.
AB - A new compound, gerfelin, was isolated from a culture broth of Beauveria felina QN22047. It was purified by column chromatography on silica gel and by HPLC. Gerfelin has the molecular formula C15H14O6. It inhibited synthesis of geranylgeranyl diphosphate, which was mediated by recombinant human geranylgeranyl diphosphate synthase (hGGPP synthase) in vitro. The inhibitory pattern of gerfelin was noncompetitive against isopentenyl diphosphate, and uncompetitive against farnesyl diphosphate.
UR - http://www.scopus.com/inward/record.url?scp=0042743761&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0042743761&partnerID=8YFLogxK
M3 - Article
C2 - 14513904
AN - SCOPUS:0042743761
VL - 56
SP - 617
EP - 621
JO - Journal of Antibiotics
JF - Journal of Antibiotics
SN - 0021-8820
IS - 7
ER -