Germacranolides from Enhydra fluctuans with TRAIL-resistance abrogating activity

Firoj Ahmed, Utpal K. Karmakar, Midori A. Arai, Naoki Ishikawa, Samir K. Sadhu, Masami Ishibashi

研究成果: Article査読

1 被引用数 (Scopus)

抄録

TRAIL selectively kills cancer cells without harming most normal cells. However, TRAIL resistance is a major problem for its therapeutic use. Developing a strategy to overcome resistance is crucial for the successful use of TRAIL as an antitumor agent. In our screening program of natural products that can abrogate TRAIL resistance, four germacranolides (1-4) were isolated from the aerial parts of Enhydra fluctuans. All compounds exhibited potent TRAILresistance overcoming activity against TRAIL-resistant human gastric adenocarcinoma (AGS) cells.

本文言語English
ページ(範囲)1169-1170
ページ数2
ジャーナルNatural product communications
12
8
DOI
出版ステータスPublished - 2017 8月
外部発表はい

ASJC Scopus subject areas

  • 薬理学
  • 植物科学
  • 創薬
  • 補完代替医療

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