Gingipains as candidate antigens for Porphyromonas gingivalis vaccine

Taneaki Nakagawa, Atsushi Saito, Yasuo Hosaka, Kazuyuki Ishihara

研究成果: Review article査読

15 被引用数 (Scopus)

抄録

Porphyromonas gingivalis (P. gingivalis), a gram-negative anaerobe, is involved in the pathogenesis of periodontal disease, and is found frequently in the subgingival flora in patients with periodontitis. This organism possesses a variety of virulence factors including lipopolysaccharide, capsular material, fimbriae and proteases (enzymes). Among the P. gingivalis antigens, enzymes such as Arginine-specific gingipains (RgpA, RgpB) and lysine-specific gingipain (Kgp) have been studied for their ability to induce biologically significant antibodies. This review summarizes recent information on the gingipains and their possible application in the development of an anti-P. gingivalis vaccine.

本文言語English
ページ(範囲)158-162
ページ数5
ジャーナルKeio Journal of Medicine
52
3
DOI
出版ステータスPublished - 2003 9

ASJC Scopus subject areas

  • 医学(全般)

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